Table 3.
Comparison of canonical pathways in aged rhesus macaques and aged olive baboons. List of all pathways reported in IPA, with pathway activation z-score and -log p-values provided for the ones detected in old rhesus macaques and old olive baboons. Pathways are ordered by activation trend and are considered significantly enriched if -log (p-value) > 1.3 (equivalent to p-value < 0.05). Enriched pathways in both NHP species are highlighted in bold
| Canonical pathways | Rhesus z-score | Baboon z-score | Rhesus -log p-value | Baboon -log p-value |
|---|---|---|---|---|
| LXR/RXR Activation | 2.0000 | 2.4490 | 2.0803 | 3.0287 |
| Paxillin Signaling | -2.0000 | -2.2360 | 2.2914 | 2.5223 |
| Leukocyte Extravasation Signaling | -1.3420 | -2.2360 | 2.7958 | 1.4927 |
| Protein Kinase A Signaling | 2.1210 | -1.3420 | 2.8470 | 1.4524 |
| Actin Cytoskeleton Signaling | -1.1340 | -1.6670 | 2.9773 | 4.0654 |
| D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis | -2.6460 | N/A | 3.7825 | 0.0000 |
| D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis | -2.6460 | N/A | 3.7825 | 0.0000 |
| 3-phosphoinositide Degradation | -2.6460 | N/A | 3.6098 | 0.0000 |
| 3-phosphoinositide Biosynthesis | -2.6460 | N/A | 3.4238 | 0.0000 |
| Integrin Signaling | -1.3420 | -1.1340 | 1.9137 | 2.4694 |
| VEGF Signaling | -0.4470 | -2.0000 | 4.3537 | 1.8903 |
| Multiple Sclerosis Signaling Pathway | 2.2360 | N/A | 1.8347 | 0.0000 |
| Intrinsic Prothrombin Activation Pathway | 2.0000 | N/A | 3.8150 | 0.4957 |
| Coagulation System | 2.0000 | N/A | 4.1297 | 0.5618 |
| Superpathway of Inositol Phosphate Compounds | -1.6670 | N/A | 4.6609 | 0.0000 |
| D-myo-inositol-5-phosphate Metabolism | -1.6670 | N/A | N/A | N/A |
| Ferroptosis Signaling Pathway | -1.0000 | 0.4470 | 3.6630 | 2.1370 |
| GP6 Signaling Pathway | 1.0000 | 0.4470 | 2.0326 | 2.2068 |
| Acute Phase Response Signaling | 1.1340 | N/A | 8.5300 | N/A |
| MicroRNA Biogenesis Signaling Pathway | 0.0000 | -1.1340 | N/A | N/A |
| Spliceosomal Cycle | N/A | -1.0000 | 0.0000 | 2.9871 |
| EIF2 Signaling | 0.0000 | -1.0000 | N/A | N/A |
| Thrombin Signaling | 1.0000 | N/A | 1.8118 | 0.4724 |
| Dilated Cardiomyopathy Signaling Pathway | N/A | -1.0000 | 0.5990 | 1.3127 |
| Complement System | 1.0000 | N/A | N/A | N/A |
| NAD Signaling Pathway | 1.0000 | N/A | 1.7796 | 0.3971 |
| Role of PKR in Interferon Induction and Antiviral Response | N/A | 1.0000 | 0.6606 | 1.4429 |
| RHOA Signaling | N/A | -0.8160 | N/A | N/A |
| Signaling by Rho Family GTPases | N/A | -0.8160 | 0.2883 | 1.4431 |
| ILK Signaling | 0.0000 | -0.7070 | N/A | N/A |
| Apoptosis Signaling | N/A | -0.4470 | N/A | N/A |
| Estrogen Receptor Signaling | 0.0000 | -0.4470 | 1.3055 | 0.4987 |
| Asparagine Degradation I | N/A | N/A | 1.8914 | 0.0000 |
| Agranulocyte Adhesion and Diapedesis | N/A | N/A | 0.8124 | 1.3602 |
| D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis | N/A | N/A | 1.9170 | 0.0000 |
| Virus Entry via Endocytic Pathways | N/A | N/A | 0.7534 | 2.3407 |
| IL-33 Signaling Pathway | N/A | N/A | 2.1435 | 0.0000 |
| Sertoli Cell-Sertoli Cell Junction Signaling | N/A | N/A | N/A | N/A |
| Protein Ubiquitination Pathway | N/A | N/A | 2.0631 | 0.3427 |
| Myo-inositol Biosynthesis | N/A | N/A | 1.4976 | 0.0000 |
| Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | N/A | N/A | 1.4523 | 0.5971 |
| Role of Tissue Factor in Cancer | N/A | N/A | 3.0278 | 0.0000 |
| Pentose Phosphate Pathway | N/A | N/A | 0.0000 | 2.3660 |
| Gluconeogenesis I | N/A | N/A | N/A | N/A |
| Tumoricidal Function of Hepatic Natural Killer Cells | N/A | N/A | N/A | N/A |
| Granzyme B Signaling | N/A | N/A | N/A | N/A |
| UVA-Induced MAPK Signaling | N/A | N/A | 2.4270 | 0.0000 |
| FAT10 Signaling Pathway | N/A | N/A | N/A | N/A |
| Remodeling of Epithelial Adherens Junctions | N/A | N/A | N/A | N/A |
| Extrinsic Prothrombin Activation Pathway | N/A | N/A | N/A | N/A |
| Regulation of Cellular Mechanics by Calpain Protease | N/A | N/A | N/A | N/A |
| Noradrenaline and Adrenaline Degradation | N/A | N/A | 0.0000 | 1.3499 |
| Thyroid Hormone Biosynthesis | N/A | N/A | 0.0000 | 1.7413 |
| GDP-L-fucose Biosynthesis I (from GDP-D-mannose) | N/A | N/A | 1.8914 | 0.0000 |
| TCA Cycle II (Eukaryotic) | N/A | N/A | 2.0203 | 0.0000 |
| CSDE1 Signaling Pathway | N/A | N/A | N/A | N/A |
| Isoleucine Degradation I | N/A | N/A | 0.0000 | 1.9398 |
| Thiamin Salvage III | N/A | N/A | 2.1910 | 0.0000 |
| FXR/RXR Activation | N/A | N/A | N/A | N/A |
| Apelin Cardiomyocyte Signaling Pathway | N/A | N/A | N/A | N/A |
| Regulation of eIF4 and p70S6K Signaling | N/A | N/A | 1.5330 | 0.0000 |
| Antigen Presentation Pathway | N/A | N/A | 1.5826 | 0.0000 |
| NADH Repair | N/A | N/A | N/A | N/A |
| Inhibition of ARE-Mediated mRNA Degradation Pathway | N/A | N/A | N/A | N/A |
| L-carnitine Biosynthesis | N/A | N/A | 0.0000 | 1.5672 |
| 2-ketoglutarate Dehydrogenase Complex | N/A | N/A | 1.5931 | 0.0000 |
| BAG2 Signaling Pathway | N/A | N/A | N/A | N/A |
| Fatty Acid β-oxidation III (Unsaturated, Odd Number) | N/A | N/A | 0.0000 | 1.4443 |
| Pentose Phosphate Pathway (Non-oxidative Branch) | N/A | N/A | N/A | N/A |
| Chronic Myeloid Leukemia Signaling | 0.0000 | N/A | N/A | N/A |
| Coronavirus Replication Pathway | N/A | N/A | N/A | N/A |
| Germ Cell-Sertoli Cell Junction Signaling | N/A | N/A | N/A | N/A |
| Tight Junction Signaling | N/A | N/A | N/A | N/A |
| Clathrin-mediated Endocytosis Signaling | N/A | N/A | N/A | N/A |
| Phagosome Maturation | N/A | N/A | N/A | N/A |
| Insulin Secretion Signaling Pathway | 0.0000 | N/A | N/A | N/A |
| Valine Degradation I | N/A | N/A | N/A | N/A |
| Gap Junction Signaling | N/A | N/A | N/A | N/A |
| Inosine-5'-phosphate Biosynthesis II | N/A | N/A | N/A | N/A |
| Ethanol Degradation II | N/A | N/A | 0.0000 | 1.3938 |
| Glycolysis I | N/A | N/A | N/A | N/A |
| Rapoport-Luebering Glycolytic Shunt | N/A | N/A | N/A | N/A |
| Glutathione Redox Reactions II | N/A | N/A | N/A | N/A |
| 14–3-3-mediated Signaling | N/A | N/A | N/A | N/A |
| Death Receptor Signaling | N/A | 0.0000 | N/A | N/A |
| PPARα/RXRα Activation | N/A | N/A | N/A | N/A |
| Iron homeostasis signaling pathway | N/A | N/A | N/A | N/A |