Table 3.

Significant cytokines and their rank variations in severe versus moderate PPGs.

Cytokines	P-adj	$\mathrm{\Delta }$Rank
CD274	0.000007	–
FLT3LG	0.000008	–
CXCL10	0.000657	+ 10
TNFSF10	0.002169	+ 54
GDF15	0.002182	+ 20
ERBB2	0.002901	+ 31
PTX3	0.003023	+ 8
CSF1	0.003947	–
SERPINA4	0.004319	− 2
PROS1	0.005541	− 1
S100A12	0.005589	− 8
MPO	0.006934	+ 60
HGF	0.007946	+ 57
ST2	0.010413	+ 30
LGALS9	0.012140	− 11
VCAM1	0.014725	− 11
IL3	0.019497	+ 52
LBP	0.029396	− 8
ADAMTS13	0.038749	− 7
FCER2	0.039913	+ 42
BDNF	0.042778	+ 47
TIMP1	0.046956	+ 34

The results of t-tests comparing cytokine SHAP values between the DP and RP groups in severe patients are shown. Here, $\mathrm{\Delta }$Rank represents the rank difference of each cytokine between the severe and moderate PPGs in terms of SHAP value. A positive $\mathrm{\Delta }$Rank indicates that the cytokine has a higher rank in the severe PPGs compared to the moderate PPGs and vice versa, while ‘–’ indicates no change in rank. For example, CXCL10 was ranked third in severe PPGs and the thirteenth in moderate PPGs, resulting in $\mathrm{\Delta }$Rank = + 10.