Fig. 1.

Correlations between APOE ε4 gene dose and lower CMRgl (shown in blue, P < 0.005, uncorrected for multiple comparisons) in cognitively normal late-middle-aged persons are projected onto the lateral and medial surfaces of the left and right cerebral hemispheres and shown in relationship to CMRgl reductions (purple and dark blue) found in previously described patients with Alzheimer's dementia (2) (purple and dark blue). Significant correlations were observed bilaterally in the precuneus (PCu), posterior cingulate (PC), left and right parietotemporal (PT), and left frontal (F) regions preferentially affected by AD (dark blue), and in adjacent PC, PCu, PT, and F regions (light blue).