Table 1. Subject characteristics, clinical ratings, and neuropsychological scores.
| Variable | ε4 homozygotes n = 36 | ε4 heterozygotes n = 46 | ε4 noncarriers n = 78 | P value |
|---|---|---|---|---|
| Age | 55.6 ± 5.2 | 56.1 ± 4.2 | 56.5 ± 4.7 | 0.52 |
| Gender (F/M) | 23/13 | 30/16 | 49/29 | 0.96 |
| Years of education | 15.8 ± 2.5 | 16.0 ± 2.6 | 15.8 ± 2.3 | 0.99 |
| MMSE | 29.7 ± 0.6 | 29.9 ± 0.4 | 29.6 ± 0.7 | 0.28 |
| HAM-D | 2.5 ± 3.3 | 1.7 ± 1.9 | 3.9 ± 4.7 | 0.08 |
| AVLT | ||||
| Total learning | 47.6 ± 8.0 | 48.5 ± 9.4 | 50.2 ± 10.2 | 0.30 |
| Short-term memory | 9.4 ± 2.5 | 10.4 ± 2.5 | 10.3 ± 3.4 | 0.07 |
| Long-term memory | 8.7 ± 2.9 | 10.0 ± 2.9 | 9.8 ± 3.4 | 0.05 |
| Complex figure test | ||||
| Copy | 34.9 ± 1.5 | 33.9 ± 2.9 | 34.3 ± 1.9 | 0.10 |
| Recall | 18.4 ± 6.1 | 19.0 ± 6.6 | 17.6 ± 6.1 | 0.60 |
| Boston naming test | 57.1 ± 3.1 | 56.8 ± 2.9 | 56.7 ± 3.4 | 0.67 |
| WAIS-R | ||||
| Information | 11.9 ± 2.2 | 12.3 ± 2.1 | 11.2 ± 2.1 | 0.06 |
| Digit span | 11.3 ± 2.2 | 11.6 ± 2.9 | 11.3 ± 2.7 | 0.81 |
| Block design | 11.9 ± 2.7 | 12.2 ± 2.7 | 11.9 ± 2.5 | 0.83 |
| Arithmetic | 11.9 ± 2.4 | 12.3 ± 2.5 | 11.4 ± 2.7 | 0.47 |
| Similarities | 12.4 ± 2.2 | 12.5 ± 2.0 | 11.8 ± 1.9 | 0.28 |
| COWAT | 44.4 ± 11.0 | 43.8 ± 11.5 | 47.7 ± 10.3 | 0.23 |
| WMS-R orientation | 13.8 ± 0.4 | 13.9 ± 0.4 | 13.7 ± 0.4 | 0.51 |
MMSE, Mini Mental State Exam; HDRS, Hamilton Depression Rating Scale; AVLT, Auditory verbal learning Test; WAIS-R, Wechsler Adult Intelligence Scale-Revised; COWAT, Controlled Oral Word Association Test; WMS-R, Wechsler Memory Scale-Revised.