Table 2. Location and magnitude of most significant correlations between APOE ε4 gene dose and regional hypometabolism.

	Atlas coordinates, mm*
Brain region	x	y	z	Correlation coefficient	P value†
Posterior cingulate	-1	-54	23	0.27	2.8 × 10-4
Precuneus	13	-80	48	0.29	1.3 × 10-4
Left parietotemporal	-43	-69	42	0.34	6.9 × 10-6
Right parietotemporal	39	-71	33	0.26	3.2 × 10-3
Left frontal	-45	1	37	0.23	1.5 × 10-3

The data were extracted from voxels associated with the most significant correlations in each predetermined AD search region.

^*The coordinates were obtained from Talairach and Tournoux (24). x is the distance to the right (+) or left (-) of the midline, y is the distance anterior (+) or posterior (-) to the anterior commissure, and z is the distance superior (+) or inferior (-) to a horizontal plane through the anterior and posterior commissures

^†The reported significance levels were computed before statistical correction for multiple comparisons. Correlations in the posterior cingulate, precuneus, left parietotemporal, and left frontal regions remained significant (P < 0.05) after correcting for multiple comparisons in the respective AD search region. Correlations in the posterior cingulate, precuneus, and left parietotemporal region remained significant (P < 0.05) after further correcting for the number of search regions