Figure 2.

Association between comorbidities and severe COVID-19 in children. OR (95% CI) = odds ratio and 95% confidence interval, estimated using data extracted from published studies. Red = Definite risk factors; Orange = Probable risk factors; Green = Unlikely risk factors; Gray = Risk modifiers. The yellow bars represent the total number of studies evaluated, with darker shades indicating the subset of studies included in the meta-analysis. ^Certainty downgraded because of small sample sizes in studies or non-significant effects after adjusting for comorbidities. *Reference age, 1–11 years.