Fig. 5.

Correlation between $\alpha$-$\beta$ interaction information and per-chain information across epitopes. Local interaction information and single-chain information across epitopes. Weighted linear fits (solid lines) obtained using orthogonal distance regression were used to quantify the dependence between variables, with regression slopes $a$ displayed above each panel. Epitope-specific interaction information depends negatively on the local informational value of the (A) $\alpha$ chain and (B) $\beta$. We furthermore find that the (C) per-chain relevancies are positively correlated with each other as is (D and E) total information with both single chain relevancies. The observed dependencies between variables agree well with theoretical expectations from a mixture model (dashed lines), in which epitopes differ in the number of distinct binding solutions or contain false positives.