The substrate scope of MCR for the synthesis of optically enriched 1,3-dioxoles^a.

^aUnless otherwise specified, all reactions were carried out using I^III/P^V-hybrid ylide 1 (0.22 mmol, 1.1 equiv.), carboxylic acid 2 (0.2 mmol, 1.0 equiv.), aldehyde 3 (0.26 mmol, 1.3 equiv.), ⁿBuMe₂N (0.40 mmol, 2.0 equiv.), 3 Å MS (40 mg), catalyst 1v (2 mol%) and DCE (2.0 mL), at −10 °C under N₂ atmosphere for 72 hours. Isolated yields were calculated. The d. r. value was determined by ¹H NMR spectroscopy. ^a96 hours reaction time. ^b−20 °C for 120 hours. ^cCatalyst 1w (2 mol%), at −20 °C for 120 hours.