Table 1. Serum concentrations of mouse SAP and human CRP in apoE−/− and apoE+/+ mice with and without transgenic human CRP.
| ApoE+/+
|
ApoE+/+-hCRP+
|
ApoE−/−
|
ApoE−/−-hCRP+
|
|||||
|---|---|---|---|---|---|---|---|---|
| Age, wk | mSAP | hCRP | mSAP | hCRP | mSAP | hCRP | mSAP | hCRP |
| Cohort A | ||||||||
| 8 | 5 (4-7) n = 4 | NA | 9 (5-12) n = 8 | 11.1 (3.0-17.7) n = 8 | 9 (5-12) n = 21 | NA | 9 (5-12) n = 11 | 10.9 (2.0-22.8) n = 11 |
| 12 | 6 (3-10) n = 7 | NA | 6 (1-8) n = 18 | 7.8 (1.1-13.7) n = 18 | 6 (3-11) n = 17 | NA | 6 (4-11) n = 17 | 17.1 (3.8-36.1) n = 17, P < 0.005 |
| 16 | 6 (2-11) n = 7 | NA | 6 (3-12) n = 20 | 6.2 (1.2-14.2) n = 20 | 6.5 (3-11) n = 18 | NA | 6 (4-11) n = 13 | 24.0 (9.8-31.2) n = 13, P < 0.0001 |
| 20 | 6 (1-7) n = 5 | NA | 4 (1-11) n = 17 | 9.1 (1.3-12.6) n = 17 | 5 (3-12) n = 27 | NA | 4.5 (1-12) n = 28 | 20.9 (1.8-41.1) n = 28, P < 0.0001 |
| Cohort B | ||||||||
| 12 | NA | ND | 17.5 (2.9-21.9) n = 5 | ND | 22.0 (11.2-32.6) n = 5, P = 0.1508 | |||
| Cohort C | ||||||||
| 56 | NA | ND | 3.5 (2.4-6.3) n = 3 | 3 (2-7) n = 16 | 27.2 (12.6-73.7) n = 16, P < 0.0001 | |||
Concentrations (mg/liter) are presented as median (range). Cohort A was bled serially at the ages shown before atherosclerosis was measured at 20 weeks. The other cohorts were bled only when atherosclerosis was measured at 12 and 56 weeks, respectively. P values for difference between CRP concentrations in apoE−/−-hCRP+ and apoE+/+-hCRP+ groups by Wilcoxon test. Note group size in cohort B is too small to provide a robust result. NA, not applicable; ND, not determined.