Table 2. Serum concentrations of estradiol and testosterone at age 50 weeks in apoE^−/− and apoE^+/+ mice with and without transgenic human CRP.

		Serum concentrations, median (range)
Genotype	n	Testosterone, nmol/liter	Estradiol*, pmol/liter	n (%) undetectable values
apoE+/+	13	1.6 (0.6-151.2)	486 (324-664)	0
apoE+/+-hCRP	18	2.4 (0.6-116.8)	471 (344-720)	0
apoE−/−	19	1.6 (0.2-79.2)	102 (49-300)	9 (47.4)
apoE−/−-hCRP	15	2.6 (0.2-49.2)	99 (99-268)	11 (73.3)
p†		0.34	0.0001	0.0001

^*The estradiol assay had a sensitivity of 50 pmol/liter. Serum samples were of limited volume and had to be diluted 1:1 or 1:2 for measurement. Values for samples that were undetectable at these dilutions are replaced by the cut-off multiplied by the dilution minus 1 (e.g., <50 when diluted at 1:2 is replaced by 99; when diluted at 1:1, it is replaced by 49). The P values obtained by nonparametric analysis are not significantly changed by using a different replacement value.

^†Kruskal-Wallis test.