Fig. 7.

Application of 3D atlas in control subjects. Registration of the SAM digital atlas (B) to various in vivo T2W test subjects of different age groups, genders, and weights using a novel processing pipeline developed within AFNI (see the Method section). (A) Mid-coronal section from the SAM atlas with delineated subcortical regions. (C–H) Coronal slices from 6 control animals, with the SAM atlas registered to the T2W MRI volume of each animal in its native space. None of the registered regions were altered or adjusted in these animals. Note that the corresponding location of the deep brain regions in the control subjects (e.g. ac, anterior commissure; Bmc, basal nucleus of the amygdala, magnocellular division, indicated by cross-hair; cd, caudate; cla, claustrum; ica, anterior limb of the internal capsule; pu, putamen) closely matched with the SAM (A). The MRI volumes of these 6 control subjects were obtained from a publicly shared multimodal brain MRI database covering marmosets with a wide age range (Hata et al. 2023). Scale bars in A–H = 5 mm.