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. Author manuscript; available in PMC: 2024 Oct 22.
Published in final edited form as: Angew Chem Int Ed Engl. 2024 Jan 24;63(9):e202317711. doi: 10.1002/anie.202317711

Figure 3.

Figure 3.

UPLC-HRMS analysis of formic acid formed from 14α-CDO dihydrolanosterol by other P450 51A enzymes in an atmosphere of 18O2. The two frames show the 18O (m/z 169.0968) and 16O (m/z 167.0925) channels for the formic acid derivative formed from the P450 51A enzymes of (A) N. fowleri, (B) C. albicans, (C) T. brucei, and (D) T. cruzi. All m/z values are calculated for the derivatized pyridyl formate esters. (The corresponding raw chromatographic traces for panel C are presented in Figure S4).