FIGURE 3.

Method comparison of type I error for bioequivalence tests of AUC_∞, AUC_last, C _max, and all metrics combined (overall) in the ophthalmic product scenarios (top) and oral product scenarios (bottom). Type I error results within the 95% binomial proportion confidence interval (top and bottom dashed lines) are not statistically significantly different from the expected 5% (middle dashed line). Please note that not every method was examined in every scenario. The bootstrapped NCA method does not produce AUC_inf. N represents the number of subjects and n represents the number of samples per subject and period in each scenario.