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. 2024 Aug 28;13(10):1748–1761. doi: 10.1002/psp4.13217

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© 2024 The Author(s). CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Method comparison of power for bioequivalence tests of AUC_∞, AUC_last, C _max, and all metrics combined (overall) in the ophthalmic product scenarios (top) and oral product scenarios (bottom). Error bars represent the 95% binomial proportion confidence interval of the power. Please note that not every method was examined in every scenario. The bootstrapped NCA method does not produce AUC_inf. N represents the number of subjects and n represents the number of samples per subject and period in each scenario.