TABLE 4.

Function groups of the enriched cellular proteins identified in rPICV virions

Functional groups	Proteins identified in rPICV virions
ESCRT pathway	Chmp1b, Chmp2a, Chmp4b, Pdcd6ip (ALIX), Tsg101, Vps37b, Vps4b, Cep55, Ist1
Ras-related proteins	Rab1a, Rab5a, Rab5b, Rab5c, Rab7a, Rab8a, Rab8b, Rab10, Rab11b, Rab13, Rab35, Rac1, Rala, Ralb, Rap1b, Rras2
Membrane re-organization, vesicle transport	Arf3, Ehd1, Ehd2, Ehd3, Ehd4, Ezr, Flot1, Flot2, Msn, Pacsin2, Sdc1, Sdc2, Sdc4, Sdcbp, Sh3gl1, YBX1
Cytoskeleton organization	Cfl1, Ezr, Krt15, Msn, Sdcbp, Tagln2, ThymB4X, Tmsb10
Receptors and signaling molecules	Cd36, Cd44, Cd81, Cd82, Cd151, Epha2, Tfr1, Gnai2, Gnb1(GNB2), Itch, Mxra8,
Transporters	Atp1a1, Atp2b1, Cacna2d1, Slc1a4, Slc1a5, Slc3a2, Slc44a2, Slc7a5, Slc16a1, Stom
Tetraspanins	Tspan5, Tspan7, Cd81, CLDN3
Other transmembrane proteins	Cspg4, Ptgfrn, Adam10, Cd63, Gja1, Jam3, Kirrel, Tmem2 (Cemip2)
Extracellular matrix (ECM) and ECM-binding proteins such as integrins	Anxa2, Anxa6, Cd81, Igsf8, Itga3, Itga5, Itgav, Itgb1-a, Mfge8, Mxra8
Chaperones	Dnaja1, Dnaja2, HSP90AA1, HSP90AB1, HSPA1A, HSPA5, HSPA8, ST13
Protein biosynthesis	Eef2, Eif4a1(ENP3), Pa2g4, PAIP1, PKM, Rack1(TRIM7, Gnb2l1), Rpl11, Rpl13, Rpl13a, Rpl15, Rpl17, Rpl18, Rpl3, Rpl4, RPL6, Rpl7, Rpl7a, Rps16, Rps18, RPS2, Rps27a, Rps3, Rps3a, Rps6, Rps8