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. 2005 Jun 10;102(25):8972–8977. doi: 10.1073/pnas.0500940102

Fig. 3.

Fig. 3.

Effects of PS transgenes on APP CTFs. (a) Western blot analysis of APP CTFs. Brain homogenates were electrophoresed on 10–20% tricine gradient gels and blotted with anti-APP C-terminal antibody C1/6.1 (47). Equal loading and transfer of protein was verified by staining the membranes with Ponceau red. Only the superimposed Tg PS1 (M146L) transgenes eliminated the accumulation of APP CTFs found in PS1 hypomorphic mice. (b) Quantitative analysis of APP CTFs that are presented on the left side of a.