Table 3.
The estimated number of rotavirus hospitalizations that occurred in 2019, the estimated number of hospitalizations that were prevented in 2019 by use of rotavirus vaccine, and the projected number of hospitalizations that can be additionally prevented with universal rotavirus vaccine introduction and vaccine coverage rates similar to DTP2, by mortality strata and WHO region.
| Estimated Number of Rotavirus Hospitalizations in 2019 (IQR; %) | Estimated number of rotavirus hospitalizations prevented in 2019 (IQR; %)* | Projected number of additional rotavirus hospitalizations that could be prevented with global introduction and higher vaccination rates (IQR; %)** | |
|---|---|---|---|
| Global Total | 1,760,113 (1,422,645–2,925,372; 100.0) | 524,871 (415,987–814,835; 100.0) | 751,609 (607,671–1,318,807; 100.0) |
| Mortality Strata | |||
| Low | 205,013 (148,682–293,532; 11.6) | 121,966 (88,454–174,627; 23.2) | 139,527 (101,190–199,771; 18.6) |
| Medium | 337,398 (297,704–921,466; 19.2) | 56,005 (49,416–152,954; 10.7) | 195,485 (172,487–533,888; 26.0) |
| High | 1,217,702 (976,258–1,710,374; 69.2) | 346,901 (278,118–487,254; 66.1) | 416,597 (333,995–585,148; 55.4) |
| WHO Region | |||
| AFR | 433,194 (347,306–608,542; 24.6) | 169,066 (135,553–237,614; 32.2) | 110,937 (88,941–155,824; 14.8) |
| AMR | 118,279 (94,883–229,030; 6.7) | 133,875 (105,860–254,826; 25.5) | 35,152 (26,969–59,512; 4.7) |
| EMR | 203,793 (165,516–321,911; 11.6) | 80,526 (64,872–121,071; 15.3) | 61,724 (50,743–107,390; 8.2) |
| EUR | 169,754 (132,433–309,540; 9.6) | 50,894 (37,721–73,989; 9.7) | 110,610 (85,635–199,587; 14.7) |
| SEAR | 501,690 (403,231–721,376; 28.5) | 82,687 (66,292–116,141; 15.8) | 224,645 (180,772–326,541; 29.9) |
| WPR | 333,403 (279,276–734,972; 18.9) | 7,822 (5,690–11,194; 1.5) | 208,541 (174,611–469,952; 27.7) |
Estimated number of hospitalizations prevented in 2019 = rotavirus vaccine VE * Expected number of hospitalizations (regional or global estimate without rotavirus vaccine) * 2018 rotavirus vaccine coverage. (limited to countries with vaccine introduction)
Estimated number of hospitalizations with global introduction and higher vaccination rates = rotavirus vaccine VE * expected number of hospitalizations (regional or global estimate without rotavirus vaccine) * 2018 DTP2 coverage – hospitalizations currently prevented. (assuming rotavirus vaccination coverage equal to that achieved by DTP2. If DTP2 coverage unknown, median of relevant mortality strata applied)