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Relationship between the levels of CoQ and ROS in human skin fibroblasts. Severe (<30% of residual CoQ10) and moderate (>50% of residual CoQ10) defects are not associated with induction of oxidative stress. However, an intermediate defect (30–50% of residual CoQ10) results in an increase of cellular ROS levels. WT, wild type. See glossary for other abbreviations.
