Table 3.
Yeast S. cerevisiae CoQ biosynthetic mutants
| Gene | CoQ6 Synthesis | Respiratory Growth | CoQ Intermediates |
|
|---|---|---|---|---|
| − | + Coq8 OE | |||
| coq1 | Absent | Absent | Not found | Not found |
| coq2 | Absent | Absent | Not found | Not found |
| coq3 | Absent | Absent | HHB↑, HAB↑* | HHB↑, HAB↑* |
| coq4 | Absent | Absent | HHB↑, HAB↑* | HHB↑, HHAB↑* |
| coq5 | Absent | Absent | HHB↑, HAB↑* | DDMQ6↑, DDMQ6↑* |
| coq6 | Absent | Absent | HHB↑, HAB↑* | 4-HP↑, 4-AP↑* |
| coq7 | Absent | Absent | HHB↑, HAB↑* | DMQ6↑, DMQ6↑* |
| coq8 | Absent | Absent | HHB↑, HAB↑* | CoQ6 |
| coq9 | Absent | Absent | HHB↑, HAB↑* | DMQ6↑, 4-HP↑, 4-AP↑* |
| coq10 | Impaired | Impaired | HHB↑, DMQ6↓ HAB↑ * | HHB↑, HAB↑* |
| coq11 | Impaired | Not affected | Not found | Not found |
*In the presence of pABA as the labeled precursor instead of labeled 4-HB. For references, see sect. 5.1.1. 4-AP, 4-aminophenol; 4-HP, 3-hexaprenyl-4-hydroxyphenol; DDMQ6, demethyldemethoxy-CoQ6; DMQ6, demethoxy-CoQ6; OE, overexpression. See glossary for other abbreviations.