Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Oct 24;44(11):2258–2263. doi: 10.1161/ATVBAHA.124.319570

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

PMC Copyright notice

Figure 1. — Multiple enzymes, including COXs (cyclooxygenases), LOXs (lipoxygenases), and CYP (cytochrome P450), generate pro-resolving oxylipins from omega-3 fatty acid (n3-FA) precursors. The n3-FAs concentrate in cell membranes and are then released enzymatically by PLA₂ (phospholipase A₂) before conversion to pro-resolving oxylipins by P450, 12/15-LOX, and COX2 (including acetylated COX2). The structures of representative oxylipins from each n3-FA are shown in the boxes on the right, where the oxygen atoms are highlighted red. 5-NGT indicates 5-nitrosoglutathione; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; EH, epoxide hydrolase; and EPA, eicosapentaenoic acid.