Table 2. Summary results of work sensitivity analysis.

Sensitivity analysis involved replacing one patient-specific parameter from the model at a time to assess how the regional work metrics were influenced by the specificity of each parameter. Each column shows the patient-specific parameters included (shaded circles) in the model and the one parameter replaced with patient-averaged values (empty circle) in the model. The sensitivity of computed volume fractions of negative work in the LV (V_fLVNW) and septum (V_fSTNW) at baseline and change after CRT to model parameters was assessed by substituting the original patient-specific (Ps) parameters with patient-averaged parameters for the geometry (G), activation times (A), mechanics (M), and hemodynamics (H). In patients with myocardial infarction, the infarct was removed (I). Sensitivity of V_fLVNW and V_fSTNW to patient-specific parameters was measured via Pearson correlation (R²) to ΔESV_LV and normalized root mean square deviation (nRMSD) from the Ps model. Patient-averaged hemodynamics and simultaneous geometry and electrical activation times (GA) eliminated the significant correlation between the outcome and the volume fraction of the LV performing negative work at LBBB. The significant correlation between ΔESV_LV and ΔV_fSTNW was eliminated using average geometry and electrical activation pattern during acute CRT.

State	LBBB							ΔCRT
Case	Ps	-G	-I	-A	-M	-H	-GA	PS	-G	-A
Model Component
Geometry	•	∘	•	•	•	•	∘	•	∘	•
Infarct	•	•	∘	•	•	•	•	•	•	•
Activation times (LBBB)	•	•	•	∘	•	•	∘	-	-	-
Biomechanics	•	•	•	•	∘	•	•	•	•	•
Hemodynamics	•	•	•	•	•	∘	•	•	•	•
Activation times (CRT)	-	-	-	-	-	-	-	•	•	∘
Regional Work Metric	R2 (ΔESVLV)
V f LVNW	0.815*	0.580*	0.823*	0.733*	0.797*	0.374	0.478	0.516*	0.087	0.183
V f STNW	0.675*	0.546*	0.752*	0.605*	0.629*	0.130	0.466	0.779*	0.499	0.044
	nRMSD (Ps)
V f LVNW	0%	14%	2%	9%	3%	31%	14%	0%	69%	34%
V f STNW	0%	33%	11%	13%	3%	33%	31%	0%	41%	47%