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. 2024 Jan 22;85(Suppl 2):e131–e144. doi: 10.1055/a-2222-0016

Table 1. Study demographics, ordered by study design and year of publication.

Authors Continent Year Study type Subtypes of repair technique Total patients Age in years (mean) Sex (M:F) Pathologies Mean tumor size (mm) BMI Follow-up
Kalamarides et al 18 Europe 2004 Prospective case series 139 NS NS VS NS NS 1 y +
Sen et al 16 Europe 2006 Prospective case series 24 51 12 M:12 F VS NS NS NS
Moderie et al 17 North America 2017 Prospective case series 94 35.5 40 M:54 F VS 24.1 NS 2.1 y
Hillman and Shelton 15 North America 2011 Prospective case series with matched cohort analysis TL cavity: fat + resorbable plate 71 51 34 M:37 F n  = 70 VS, n  = 1 meningioma 20 NS NS
TL cavity: fat closure 149 49.8 a 68 M:81 F n  = 147 VS, n  = 2 meningioma 22 NS NS
Brennan et al 57 North America 2001 Retrospective case series 431 NS NS VS 21.3 NS NS
Leonetti et al 31 North America 2001 Retrospective case series 209 56.4 1 M: 1.18 F VS 77%, meningioma 10%, paraganglioma 7%, other 6% <1 cm 23%, 1.1–2.0 cm 17%, 2.1–3 cm 40%, >3 cm 20% NS NS
Arriaga and Chen 21 North America 2002 Retrospective case series AFG 54 NS 26 M:28 F VS 22 NS 1 y+
HAC 1 (hardened cement contacts dura 7 NS 24 M:30 F VS NS
HAC 2 (fat contacts dura, then filled with HAC) 47 NS
Becker et al 10 North America 2003 Retrospective case series 100 51 50 M:50 F VS 22 NS NS
Sanna et al 32 Europe 2003 Retrospective case series 596 NS NS VS NS NS NS
Cueva and Mastrodimos 64 North America 2005 Retrospective case series 126 NS NS VS 20 NS NS
Hussain and Ahsan 46 North America 2005 Retrospective case series 20 54.4 7 M:3 F VS NS 6 mo
Arriaga et al 38 North America 2007 Retrospective case series 90 NS NS 22
Fayad et al 41 North America 2007 Retrospective case series 389 47.6 187 M: 202 F VS 24 NS NS
Jacob et al 19 North America 2007 Retrospective case series ET packing 148 NS NS NS NS NS NS
North America 2007 Retrospective case series No ET packing 51 NS NS NS NS NS NS
Roche et al 37 Europe 2008 Retrospective case series 110 50.1 44 M:66 F VS Stage IV (KOOS) NS NS
Yuen et al 29 North America 2009 Retrospective case series TL cavity: vascularized mastoid bone flap 17 56.5 7 M:10 F VS 30 NS 12–15 mo
TL cavity: fat packing 10 51.3 6 M:4 F VS 28 NS 1 y+
Charpiot et al 59 Europe 2009 Retrospective case series 123 46.4 62 M:61 F VS Stage IV KOOS NS 1 y+
Wiet et al 39 North America 2000 Retrospective case series 44 57.8 21 M:23 F VS 19 NS NS
Khrais et al 33 Europe 2004 Retrospective case series 710 50.5 332 M:378 F VS 20 NS
Fishman et al 40 North America 2004 Retrospective case series 101 NS NS VS NS NS NS
Goddard et al 35 North America 2010 Retrospective case series 61 46.6 27 M:34 F VS 23 NS 31.3 mo
Bambakidis et al 50 North America 2010 Retrospective case series 15 53.5 7 M:8 F VS 12 a NS NS
Angeli et al 54 Europe 2011 Retrospective case series 110 42.5 51 M:59 F VS 41 NS 1 y+
Netto et al 28 South America 2012 Retrospective case series Dural repair: fat plugging 18 51.47 13 M: 21 F VS 23 NS 1 y+
Dural repair: synthetic dura + fat plugging 16 NS NS
Ben Ammar et al 34 Africa 2012 Retrospective case series 1,865 50.39 886 M:979 F VS 18 NS 5.7 y
Liu et al 22 North America 2012 Retrospective case series Dural repair: fascial sling 8 55.6 5 M:3 F VS NS NS 13.8 mo
Dural repair: synthetic sling 5 49.6 1 M:4 F VS NS NS 35.8 mo
Zhang et al 58 Asia 2012 Retrospective case series 115 46.42 50 M:65 F VS 40.7 NS 1 y+
Manjila et al 47 North America 2013 Retrospective case series 42 50.5 21 M:21 F VS 15.1 NS NS
Boghani et al 45 North America 2013 Retrospective case series 13 51.9 b 1 M:1.33 F b VS NS NS NS
Hunter et al 48 North America 2015 Retrospective case series 53 54 29 M:34 F CPA tumors 18.8 30.8 5.4 mo
Crowson et al 12 North America 2016 Retrospective case series Lumbar drain 110 52.3 b 1 M:1.33 F b VS 19.1 b NS NS
North America 2016 Retrospective case series No lumbar drain 11 52.3 b 1 M:1.33 F b VS 19.1 b NS NS
Volsky et al 36 North America 2017 Retrospective case series 369 NS NS VS NS NS Pittsburgh 5.2 y, Louisiana 577 d
Russel et al 55 Europe 2017 Retrospective case series 275 55.4 a 122 M:153 F VS NS 25.3 a NS
Ölander et al 56 Europe 2018 Retrospective case series 700 53 330 M:370 F VS 27 NS NS
Luryi et al 30 North America 2020 Retrospective case series 52 56.2 27 M:25 F VS 51, meningioma 1 22 NS 30.5 mo
Plainfossé et al 23 Europe 2022 Retrospective case series Without ET packing 8 53.6 4.55 M:1 F b VS NS 25.7 5.5 y
Plainfossé et al 23 Europe 2022 Retrospective case series With ET packing 39 53.6
Cooper et al 42 North America 2021 Retrospective case series 23 57 9 M:14 F VS NS NS 21 mo
Totten et al 25 North America 2021 Retrospective case series Dural autograft 56 49 NS VS = 54, FN schwannoma = 2 22 27.7 ( a ) 15 mo a
Dural xenograft 21 47 NS VS = 18, epidermoid = 2, meningioma = 1 25 27.7 ( a ) 14 mo a
Selleck et al 27 North America 2021 Retrospective case series TL cavity: fat only 38 56.4 13 M:25 F VS 19.6 30.7 691 d
TL cavity: fat + plate 94 51 40 M:54 F VS 22 30.5 3,369 d
Martinez-Perez et al 24 Europe 2022 Retrospective case series Tl cavity: mastoid fat + HAC 34 49.7 14 M:20 F CPA tumors NS NS NS
Retrospective case series TL cavity: mastoid fat 35 50.7 17 M:18 F NS NS NS
Sioshansi et al 20 North America 2021 Retrospective case series TL cavity: Fat Graft 30 53.67 14 M:16 F VS 19.36 27.5 3 mo+
TL cavity: HAC 33 54.8 13 M:17 F VS 20.6 28.9 3 mo +
Freeman et al 49 North America 2023 Retrospective case series 205 52.5 77 M:128 F VS 23 28.8 NS
Christopher et al 26 North America 2021 Retrospective case series with matched cohort analysis Mastoid approach 102 51 45 M: 57 F VS 24.1 NS NS
Retrospective case series with matched cohort analysis Facial recess approach 102 49 48 M:54 F VS 24.2 NS NS

Abbreviations: AAA, aditus ad antrum; BW, bone wax; CSF, cerebrospinal fluid; ET, eustachian tube; HAC, hydroxyapatite cement; LD, lumbar drain; ME, middle ear; NS, not specified; s/c, subcutaneous; TL, translabyrinthine; WT, watertight.

a

Median.

b

Value averaged from larger dataset.