Table 4:
Growth Parameters in infants with and without severe ROP
| NEC + SIP | NEC Cohort | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All | No ROP | Type 1 or 2 ROP | No ROP | Type 1 or 2 ROP | ||||||
| At birth | n | n=66 | n=39 | n=27 | p | n | n=46 | n=28 | n=18 | p |
| Weight (z score) | 66 | −0.32 [−0.82;0.41] | −0.19 [−0.80;0.48] | −0.39 [−0.84;0.14] | 0.49 | 46 | −0.36 [−0.96;0.28] | −0.24 [−0.96;0.34] | −0.44 [−1.24;0.08] | 0.73 |
| Total length (cm, median [IQR]) | 66 | 31.6 [30.4;34.5] | 34.0 [31.6;38.2] | 30.5 [28.8;31.2] | <0.001 | 46 | 31.6 [30.1;34.5] | 34.1 [30.9;39.2] | 30.5 [28.8;31.5] | 0.001 |
| Total length (z score) | 66 | −0.37 [−1.11;0.17] | −0.33 [−1.09;0.20] | −0.38 [−1.09;0.07] | 0.56 | 46 | −0.40 [−1.43;0.14] | −0.50 [−1.77;0.14] | −0.32 [−1.21;−0.04] | 0.99 |
| Weight for total length (percentile) | 66 | 41.6 [24.3;61.9] | 50.3 [25.7;63.6] | 36.1 [18.5;45.1] | 0.05 | 46 | 41.7 [22.7;62.4] | 49.3 [26.0;66.0] | 35.1 [15.8;45.3] | 0.09 |
| Weight and total length (z score) | 66 | −0.21 [−0.70;0.33] | −0.04 [−0.68;0.34] | −0.31 [−0.80;−0.02] | 0.24 | 46 | −0.18 [−0.73;0.35] | −0.01 [−0.65;0.42] | −0.31 [−0.88;0.03] | 0.3 |
| Head circumference (cm, median [IQR]) | 66 | 22.5 [21.5;24.0] | 24.0 [22.5;26.8] | 21.5 [21.0;22.2] | <0.001 | 46 | 23.0 [21.5;24.5] | 24.0 [22.4;27.5] | 21.5 [21.5;22.9] | 0.002 |
| Head circumference (z score) | 66 | −0.30 [−1.14;0.30] | −0.19 [−1.17;0.30] | −0.48 [−1.11;0.19] | 0.94 | 46 | −0.36 [−1.24;0.30] | −0.19 [−1.96;0.32] | −0.49 [−1.13;0.00] | 0.89 |
| Before NEC | n=71 | n=41 | n=30 | n=50 | n=30 | n=20 | ||||
| Weight (z score) | 71 | −1.00 [−1.43;−0.36] | −0.98 [−1.43;−0.29] | −1.06 [−1.47;−0.44] | 0.35 | 50 | −1.02 [−1.59;−0.50] | −0.98 [−1.43;−0.28] | −1.31 [−1.68;−0.71] | 0.1 |
| Total length (cm, median [IQR]) | 71 | 35.3 [33.0;39.1] | 37.5 [34.2;41.0] | 33.5 [30.6;35.2] | <0.001 | 50 | 35.4 [33.4;39.5] | 37.5 [34.3;40.8] | 33.8 [30.8;35.1] | 0.001 |
| Total length (z score) | 71 | −1.28 [−2.20;−0.36] | −0.68 [−1.97;0.00] | −1.69 [−2.49;−1.14] | 0.007 | 50 | −1.41 [−2.33;−0.51] | −1.00 [−2.19;−0.05] | −1.72 [−2.80;−1.14] | 0.033 |
| Weight and total length (percentile) | 71 | 28.4 [12.5;45.8] | 29.8 [12.3;43.3] | 27.4 [12.9;50.3] | 0.68 | 50 | 29.0 [12.7;46.4] | 30.1 [13.4;47.8] | 20.8 [11.8;41.9] | 0.44 |
| Weight and total length (z score) | 71 | −0.53 [−1.14;−0.11] | −0.52 [−1.13;−0.17] | −0.60 [−1.13;0.00] | 0.79 | 50 | −0.55 [−1.14;−0.09] | −0.52 [−1.10;−0.06] | −0.82 [−1.19;−0.21] | 0.43 |
| Head circumference (cm, median [IQR]) | 71 | 25.0 [23.0;28.7] | 26.5 [24.2;30.3] | 24.0 [21.5;26.4] | 0.003 | 50 | 25.2 [23.6;28.4] | 26.5 [24.5;30.0] | 24.0 [21.9;26.1] | 0.010 |
| Head circumference (z score) | 71 | −1.43 [−1.98;−0.41] | −0.98 [−1.81;−0.29] | −1.75 [−2.64;−1.17] | 0.014 | 50 | −1.52 [−2.55;−0.41] | −0.99 [−1.77;−0.31] | −1.95 [−2.94;−1.33] | 0.038 |
| 4 weeks after NEC | n=68 | n=39 | n=29 | n=47 | n=28 | n=19 | ||||
| Weight (z score) | 68 | −1.19 [−1.89;−0.64] | −1.21 [−1.74;−0.54] | −1.18 [−1.98;−0.66] | 0.55 | 47 | −1.26 [−1.90;−0.64] | −1.23 [−1.66;−0.55] | −1.37 [−2.03;−0.65] | 0.48 |
| Total length (cm, median [IQR]) | 68 | 40.0 [35.3;43.1] | 42.0 [38.8;44.5] | 36.0 [33.5;40.0] | <0.001 | 47 | 40.0 [35.7;44.0] | 42.1 [40.0;44.6] | 36.0 [34.0;39.2] | <0.001 |
| Total length (z score) | 68 | −1.77 [−2.59;−1.01] | −1.47 [−2.29;−0.62] | −2.10 [−3.31;−1.69] | 0.003 | 47 | −2.04 [−2.64;−1.04] | −1.65 [−2.32;−0.62] | −2.51 [−3.46;−1.73] | 0.012 |
| Weight and total length (percentile) | 68 | 20.3 [6.24;42.7] | 20.7 [6.66;49.9] | 20.1 [5.50;40.4] | 0.88 | 47 | 19.2 [6.66;43.2] | 19.8 [7.48;49.4] | 19.2 [5.44;37.4] | 0.57 |
| Weight and total length (z score) | 68 | −0.82 [−1.49;−0.07] | −0.82 [−1.50;0.00] | −0.82 [−1.45;−0.22] | 0.74 | 47 | −0.84 [−1.47;−0.05] | −0.85 [−1.45;−0.02] | −0.84 [−1.52;−0.13] | 0.96 |
| Head circumference (cm, median [IQR]) | 68 | 28.0 [25.4;30.0] | 29.5 [27.5;32.1] | 26.2 [23.8;28.5] | 0.001 | 47 | 28.0 [26.3;30.6] | 29.5 [27.6;32.3] | 26.9 [24.2;28.4] | 0.005 |
| Head circumference (z score) | 68 | −2.08 [−3.04;−1.05] | −1.44 [−2.49;−0.88] | −2.58 [−3.20;−2.03] | 0.013 | 47 | −2.00 [−2.83;−1.04] | −1.47 [−2.34;−0.98] | −2.44 [−3.27;−1.92] | 0.06 |
| Before reanastomosis | n=56 | n=30 | n=26 | n=37 | n=21 | n=16 | ||||
| Weight (z score) | 56 | −1.48 [−2.19;−0.85] | −1.30 [−2.00;−0.71] | −1.80 [−2.48;−0.98] | 0.1 | 37 | −1.49 [−2.18;−0.87] | −1.30 [−2.16;−0.58] | −1.75 [−2.59;−1.07] | 0.27 |
| Total length (cm, median [IQR]) | 56 | 44.2 [41.5;47.1] | 45.0 [42.0;47.9] | 43.0 [41.1;46.4] | 0.1 | 37 | 44.0 [41.0;47.0] | 46.0 [42.0;48.0] | 41.8 [38.9;44.5] | 0.032 |
| Total length (z score) | 56 | −1.94 [−3.01;−1.13] | −1.36 [−2.01;−0.76] | −2.49 [−3.38;−1.96] | <0.001 | 37 | −2.10 [−3.06;−1.05] | −1.44 [−2.18;−0.75] | −2.91 [−3.48;−2.33] | <0.001 |
| Weight and total length (percentile) | 56 | 17.4 [3.69;42.0] | 17.4 [6.52;33.5] | 15.8 [2.35;58.1] | 0.83 | 37 | 16.9 [2.59;42.7] | 16.9 [3.01;35.2] | 15.8 [2.51;52.6] | 0.76 |
| Weight and total length (z score) | 56 | −0.94 [−1.79;−0.20] | −0.94 [−1.51;−0.43] | −1.01 [−1.98;0.21] | 0.82 | 37 | −0.96 [−1.94;−0.18] | −0.96 [−1.88;−0.38] | −1.01 [−1.96;0.07] | 0.77 |
| Head circumference (cm, median [IQR]) | 56 | 30.6 [28.6;32.6] | 30.8 [30.0;33.5] | 30.1 [28.5;31.7] | 0.27 | 37 | 30.5 [28.7;31.8] | 30.5 [30.0;33.5] | 29.7 [27.6;31.6] | 0.3 |
| Head circumference (z score) | 56 | −2.19 [−2.79;−1.21] | −1.62 [−2.54;−0.82] | −2.50 [−3.12;−1.77] | 0.008 | 37 | −2.26 [−2.92;−1.52] | −1.90 [−2.86;−0.98] | −2.41 [−3.23;−1.95] | 0.1 |
| At 36 weeks | n=65 | n=35 | n=30 | n=46 | n=26 | n=20 | ||||
| Weight (z score) | 65 | −1.43 [−2.00;−0.76] | −1.05 [−1.71;−0.62] | −1.73 [−2.31;−1.07] | 0.027 | 46 | −1.50 [−2.11;−0.68] | −1.12 [−1.84;−0.47] | −1.86 [−2.55;−1.13] | 0.037 |
| Total length (cm, median [IQR]) | 65 | 42.3 [40.0;44.5] | 43.0 [41.5;45.0] | 41.3 [40.0;43.0] | 0.008 | 46 | 42.0 [40.0;44.9] | 43.1 [41.2;45.0] | 41.3 [39.8;43.0] | 0.040 |
| Total length (z score) | 65 | −1.67 [−2.60;−1.09] | −1.50 [−2.21;−0.76] | −2.21 [−3.21;−1.34] | 0.035 | 46 | −1.83 [−3.02;−0.84] | −1.63 [−2.30;−0.63] | −2.35 [−3.34;−1.50] | 0.09 |
| Weight and total length (percentile) | 65 | 16.8 [3.88;37.3] | 23.2 [8.14;43.1] | 10.7 [2.46;33.0] | 0.08 | 46 | 16.2 [2.96;42.0] | 23.2 [4.24;46.9] | 8.02 [2.05;25.6] | 0.049 |
| Weight and total length (z score) | 65 | −0.96 [−1.76;−0.32] | −0.73 [−1.44;−0.17] | −1.25 [−1.97;−0.45] | 0.08 | 46 | −0.98 [−1.89;−0.20] | −0.73 [−1.72;−0.08] | −1.40 [−2.08;−0.66] | 0.05 |
| Head circumference (cm, median [IQR]) | 65 | 29.5 [28.3;31.5] | 31.0 [29.4;31.9] | 28.8 [27.6;29.5] | 0.001 | 46 | 29.5 [28.2;31.7] | 30.5 [29.1;31.8] | 29.0 [27.3;29.6] | 0.029 |
| Head circumference (z score) | 65 | −1.96 [−2.75;−0.85] | −1.32 [−2.24;−0.45] | −2.60 [−3.35;−2.02] | 0.001 | 46 | −2.04 [−2.88;−0.66] | −1.40 [−2.55;−0.45] | −2.52 [−3.63;−1.98] | 0.027 |
| Discharge | n=63 | n=35 | n=28 | n=43 | n=25 | n=18 | ||||
| Weight (z score) | 63 | −1.69 [−2.67;−0.63] | −1.63 [−2.66;−0.66] | −1.90 [−2.66;−0.19] | 0.98 | 43 | −1.87 [−2.98;−0.89] | −1.68 [−2.94;−0.65] | −2.02 [−2.98;−1.61] | 0.48 |
| Total length (cm, median [IQR]) | 63 | 51.5 [49.5;58.9] | 51.5 [48.4;58.9] | 51.6 [49.9;57.5] | 0.63 | 43 | 52.0 [49.5;56.4] | 54.2 [50.0;60.0] | 50.5 [49.5;53.8] | 0.13 |
| Total length (z score) | 63 | −1.74 [−3.46;−0.92] | −1.57 [−3.33;−0.59] | −2.34 [−3.46;−1.53] | 0.14 | 43 | −2.38 [−3.60;−1.50] | −1.71 [−3.66;−0.99] | −2.90 [−3.46;−1.94] | 0.16 |
| Weight and total length (percentile) | 63 | 48.2 [13.6;93.8] | 22.0 [3.18;71.0] | 77.5 [46.7;97.6] | 0.003 | 43 | 59.0 [20.6;95.4] | 28.7 [5.80;94.0] | 76.7 [43.6;97.9] | 0.07 |
| Weight and total length (z score) | 63 | 0.02 [−1.33;1.54] | −0.77 [−1.91;0.55] | 0.76 [0.00;1.97] | 0.002 | 43 | 0.24 [−0.98;1.71] | −0.63 [−2.18;1.56] | 0.74 [0.02;2.05] | 0.06 |
| Head circumference (cm, median [IQR]) | 63 | 35.7 [34.0;38.5] | 35.5 [34.0;38.0] | 36.1 [34.0;38.6] | 0.61 | 43 | 36.0 [34.0;38.0] | 36.5 [34.5;38.5] | 35.0 [33.7;37.0] | 0.23 |
| Head circumference (z score) | 63 | −2.02 [−3.21;−1.06] | −1.64 [−2.63;−0.33] | −2.40 [−3.36;−1.69] | 0.031 | 43 | −2.02 [−3.49;−1.16] | −1.81 [−3.29;−0.51] | −2.57 [−3.66;−1.72] | 0.18 |
Notes: All continuous data was represented as median (Interquartile range, IQR). P values were based on Mann-Whitney U-test. IQR was represented as (Quartile 1; Quartile 3)