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Pharmacokinetics parameters of sorafenib nanoformulation
| Parameter | Cmax | AUC0-t | AUMC∞ | MRT | t½ | Vd | Cl |
|---|---|---|---|---|---|---|---|
| μgml-1 | μghrml-1 | µghr2ml-1 | Hr | Hr | ml | mlh-1 kg-1 | |
| References/control | 4.1 ± 0.011 | 15.0 ± 0.014 | 282.3 ± 1.12 | 12.0 ± 0.05 | 9.54 ± 0.14 | 5,881.1 ± 1.56 | 426.856 ± 0.098 |
| Sorafenib Polox50 |
4.3 ± 0.048 | 140.3 ± 1.94 | 200,923.8 ± 537.15 | 527.9 ± 1.78 | 374.09 ± 3.34 | 14,288.2 ± 0.52 | 26.469 ± 0.014 |
| p-value | 0.001*** | 0.001*** | 0.001*** | 0.001*** | 0.001*** | 0.001*** |
