Table 2.
Mean (SD) values for EORTC QLQ-C30 scales at 1.5 and 3 years post-diagnosis; changes over time with effect sizes
| Scores and changes, all diagnoses | Mean scores by diagnosis | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Score Mean (SD) |
Change Mean (SD) |
Effect size Cohen’s d |
Lymphoma Mean (SD) |
Breast cancer Mean (SD) |
Cervical cancer Mean (SD) |
Ovarian cancer Mean (SD) |
Brain tumor Mean (SD) |
Testicular cancer Mean (SD) |
|
| Global QoL | |||||||||
|
1.5 years 3 years |
65.8 (20.7) 68.4 (19.4) |
+ 1.5 (19.2) | 0.08 | 66.2 (19.6)68.6 (17.3) |
63.3 (19.6) 66.9 (19.9) |
65.5 (22.6) 68.4 (19.9) |
56.5 (23.5) 65.9 (15.2) |
65.8 (20.5) 68.1 (21.4) |
71.8 (19.8) 71.6 (18.3) |
| Physical Function | |||||||||
|
1.5 years 3 years |
87.0 (16.7) 90.6 (14.0) |
+ 2.1 (13.9) | 0.15 | 86.0 (17.3)89.6 (13.8) |
84.9 (16.9) 89.5 (13.6) |
87.9 (17.3) 90.9 (13.8) |
81.2 (22.2) 90.6 (13.9) |
84.7 (16.5) 87.2 (18.7) |
93.1 (12.2) 94.9 (10.0) |
| Role Function | |||||||||
|
1.5 years 3 years |
77.9 (29.6) 85.6 (24.6) |
+ 6.4 (29.4) | 0.22 | 79.1 (27.8)84.9 (23.1) |
73.5 (30.0) 83.6 (24.5) |
81.2 (29.4) 87.0 (25.4) |
67.2 (38.8) 86.4 (26.0) |
67.5 (32.8) 76.6 (31.6) |
89.8 (20.6) 94.0 (16.0) |
| Emotional Function | |||||||||
|
1.5 years 3 years |
63.3 (25.8) 67.2 (24.2) |
+ 3.4 (23.4) | 0.15 | 60.9 (24.8)66.4 (24.0) |
58.2 (25.3) 65.2 (24.2) |
63.2 (27.6) 66.0 (24.0) |
56.8 (30.4) 59.1 (24.2) |
68.9 (23.4) 67.5 (24.7) |
71.3 (23.7) 73.7 (23.6) |
| Social Function | |||||||||
|
1.5 years 3 years |
73.5 (30.2) 81.1 (26.3) |
+ 6.0 (26.4) | 0.23 | 75.7 (30.1)81.8 (24.4) |
65.0 (31.1) 75.2 (27.9) |
77.6 (29.3) 84.4 (26.4) |
65.1 (37.7) 87.9 (21.9) |
72.4 (29.3) 76.3 (28.9) |
85.3 (23.6) 90.9 (18.9) |
| Cognitive Function | |||||||||
|
1.5 years 3 years |
69.8 (27.3) 72.0 (26.4) |
+ 1.8 (23.2) | 0.08 | 71.3 (23.4)71.6 (24.5) |
63.2 (28.9) 67.6 (27.7) |
71.1 (27.1) 73.8 (26.1) |
64.6 (29.3) 70.4 (23.0) |
71.2 (26.5) 69.3 (26.0) |
79.1 (23.5) 80.8 (23.7) |
| Fatigue | |||||||||
|
1.5 years 3 years |
39.2 (27.2) 35.4 (25.0) |
− 2.3 (22.7) | 0.10 | 40.3 (25.8)39.9 (21.0) |
44.0 (26.3) 38.4 (26.5) |
37.1 (28.4) 31.9 (24.7) |
49.1 (29.8) 44.4 (21.7) |
42.9 (26.8) 39.3 (26.3) |
27.8 (24.4) 26.7 (21.7) |
| Nausea/Vomiting | |||||||||
|
1.5 years 3 years |
7.8 (15.1) 6.2 (12.7) |
− 1.3 (16.7) | 0.08 | 9.3 (17.1)7.4 (13.0) |
6.9 (12.6) 8.0 (15.4) |
10.2 (17.2) 5.4 (11.1) |
15.1 (21.7) 9.8 (13.3) |
7.6 (14.1) 5.4 (10.5) |
5.2 (14.7) 3.0 (7.9) |
| Pain | |||||||||
|
1.5 years 3 years |
21.9 (26.1) 19.0 (23.8) |
− 1.8 (24.0) | 0.08 | 19.9 (22.1)18.0 (23.4) |
28.2 (28.5) 23.3 (25.8) |
19.7 (25.6) 18.8 (23.3) |
28.6 (32.6) 21.2 (21.3) |
19.0 (25.1) 15.9 (21.3) |
14.5 (20.4) 13.6 (21.5) |
| Dyspnea | |||||||||
|
1.5 years 3 years |
31.8 (30.3) 30.0 (29.2) |
− 1.7 (32.8) | N/A | 39.1 (32.2)34.7 (30.7) |
33.2 (30.1) 28.8 (29.1) |
26.8 (29.7) 29.1 (30.9) |
35.4 (33.8) 24.2 (23.4) |
30.0 (28.7) 32.6 (30.6) |
30.1 (29.7) 29.7 (26.9) |
| Sleep Disturbances | |||||||||
|
1.5 years 3 years |
34.2 (32.6) 31.3 (32.0) |
− 0.9 (31.6) | N/A | 37.1 (32.7)35.6 (33.3) |
41.4 (32.4) 35.8 (33.1) |
34.2 (34.2) 27.3 (31.3) |
31.2 (30.5) 34.8 (37.8) |
30.6 (33.2) 30.7 (32.1) |
22.3 (27.3) 24.2 (27.5) |
| Appetite Loss | |||||||||
|
1.5 years 3 years |
12.7 (23.6) 8.8 (19.4) |
− 2.0 (23.7) | 0.08 | 14.3 (22.6)9.9 (17.2) |
12.3 (23.4) 9.4 (21.8) |
15.2 (26.3) 8.7 (17.5) |
20.8 (31.4) 6.1 (16.7) |
15.7 (24.7) 11.5 (21.9) |
6.9 (18.2) 5.6 (15.4) |
| Constipation | |||||||||
|
1.5 years 3 years |
12.0 (23.2) 11.8 (23.7) |
0.0 (26.7) | N/A | 10.1 (21.7)9.0 (17.7) |
14.8 (25.3) 15.0 (26.9) |
14.8 (25.5) 13.4 (24.6) |
13.5 (22.2) 15.2 (24.6) |
13.0 (25.2) 14.1 (26.4) |
4.4 (12.7) 3.6 (13.2) |
| Diarrhea | |||||||||
|
1.5 years 3 years |
10.6 (20.7) 10.3 (19.9) |
+ 0.5 (24.3) | N/A | 13.6 (22.9)10.4 (15.5) |
8.6 (18.1) 7.2 (17.6) |
13.7 (24.2) 15.6 (24.6) |
10.4 (23.1) 12.1 (19.4) |
9.4 (20.3) 10.7 (20.5) |
10.5 (19.4) 10.6 (20.1) |
| Financial Difficulties | |||||||||
|
1.5 years 3 years |
20.0 (31.4) 14.6 (28.2) |
− 3.0 (25.7) | 0.12 | 21.3 (30.4)13.1 (25.2) |
26.5 (34.7) 15.6 (29.0) |
13.0 (25.6) 10.6 (24.5) |
25.0 (36.9) 22.7 (34.7) |
22.8 (34.3) 25.2 (35.8) |
11.8 (24.2) 9.2 (22.0) |
Shown overall and stratified by cancer type. Missing values per diagnosis = 0–6. Missing values for total sample = 13–18. Missing values for change over time (total sample, 17–24). Significant changes over time (two-tailed P < 0.05 in paired t-tests) in bold
N/A not applicable, QoL quality of life, SD standard deviation
Bold values indicate statistical significance