Table 2. Clinical and biomarker correlations in patients with resistant hypertension evaluated in the study (N= 115).

Reference ranges: PRA (ng/ml/hour): lying position: 0.15-2.33, standing position: 0.10-6.56; S Aldosterone (ng/dL): upright: 2.52-39.2, supine: 1.76-23.2; S Creatinine (mg/dl): women 0.55-1.02, men 0.72-1.18

R value= Correlation coefficient. P value= P<0.05 was considered statistically significant; P≥0.05 not significant.

PRA: plasma renin activity; S: serum; eGFR: estimated glomerular filtration rate; HTN: hypertension; SBP: systolic blood pressure; DBP: diastolic blood pressure; A:C: albumin:creatinine; ECHO EF%: echocardiography ejection fraction %; ARR: aldosterone renin ratio

Biomarker	Reference Range	Units	ARR versus		PRA versus		Serum Aldosterone versus
All (N= 115)	-	-	R value	P value	R value	P value	R value	P value
Baseline	-	-	-	-	-	-	-	-
Age	-	years	0.14	0.13	-0.35	0.0001	-0.14	0.15
PRA	0.10-6.56	ng/ml/hr	-0.28	0.002	-	-	0.01	0.90
S Aldosterone	2.52-39.2	ng/dL	0.55	1E-10	0.01	0.90	-	-
HTN duration	-	years	0.10	0.32	-0.21	0.05	-0.01	0.89
SBP highest	90-120	mmHg	-0.08	0.51	0.10	0.45	-0.19	0.13
DBP highest	60-80	mmHg	0.04	0.75	0.01	0.91	0.11	0.38
S Creatinine	0.55-1.18	mg/dl	0.23	0.03	0.05	0.66	0.13	0.24
eGFR	-	ml/minute/1.73m2	-0.24	0.02	0.05	0.63	-0.04	0.69
Urine A:C ratio	<30	µg/mg	0.04	0.74	-0.13	0.27	0.02	0.86
S Sodium	135-150	mEq/L	-0.05	0.66	0.10	0.36	0.05	0.64
S Potassium	3.5-5.4	mEq/L	-0.06	0.59	-0.13	0.26	-0.16	0.15
Current/Follow-Up	-	-	-	-	-	-	-	-
SBP current	90-120	mmHg	-0.12	0.36	-0.04	0.77	0.10	0.46
DBP current	60-80	mmHg	-0.09	0.52	0.3	0.02	0.17	0.23
Comorbidities	-	-	-	-	-	-	-	-
ECHO EF%	50-70	%	-0.14	0.22	0.15	0.20	0.01	0.93