TABLE 7.
Viremia after YF/DEN1-4 tetravalent immunization (total dose, 5.4 log10 PFU) in YF-immune and nonimmune monkeys
| YF immune | Monkey | Viremia (log10 PFU/ml) by post-secondary immunization day:
|
Mean
|
Serotype isolatede (day[s]) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11f | Peak titerb (SD) | Durationc (SD) | |||
| Yes | BA29 | —a | 2.0 | 1.4 | — | — | — | — | — | — | — | — | 1.3 (0.9) | 1.5 (0.7) | 1, 2 (2–3) |
| V576 | — | — | — | — | — | — | — | — | — | — | — | ||||
| V202 | — | — | 0.7 | — | — | — | — | — | — | — | — | 2 (3) | |||
| No | BF33 | 1.0 | 2.5 | 2.2 | 1.4 | — | — | — | — | — | — | — | 2.4 (0.2) | 4.7 (1.5) | 2 (1–4) |
| BF29 | — | 2.3 | 2.5 | 1.9 | — | — | — | — | — | — | — | 2 (2–4), 3 (3) | |||
| BJ43 | 1.4 | 2.1 | 2.1 | 1.4 | — | — | — | — | — | 1.4 | 2.2 | 2 (1–4), 4 (10–11) | |||
| BD24 | 1.4 | 2.6 | 2.0 | 1.4 | — | 1.4 | — | — | 0.7 | — | — | 2 (3, 4, 6, 9) | |||
| BB88 | 1.0 | 2.5 | 2.4 | 1.9 | 1.0 | 1.0 | — | — | — | — | — | 2 (1, 2, 4, 6) | |||
| BG30 | — | 2.2 | 2.1 | 1.7 | — | — | — | — | — | — | — | 2 (2–4) | |||
| Pd | 0.007 | 0.007 | |||||||||||||
a
—, <0.7 log10 PFU/ml.).
b
Log10 PFU per milliliter
c
Days.
d
Peak titers and duration of viremia in YF-immune group were compared to values from non immune group by t test (JPM version 4.0.2).
e
Determined by RT-PCR followed by HindIII digestion.
f
No viremia was detected after this day.