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. 2024 Oct 22;15:9106. doi: 10.1038/s41467-024-53376-1

Fig. 3. Combined effects of Trp53 loss and LMP1 expression on normal and malignant NK cells.

Fig. 3

a Kaplan–Meier survival curves of Trp53−/− (n = 65), LMP1+ (n = 25), and Trp53−/−LMP1+ (n = 41) mice. Log-rank test. No adjustments were made for multiple comparisons. Trp53−/− data are the same as in Fig. 1a. b CBC in PB of Trp53−/− (n = 37) and Trp53−/−LMP1+ (n = 22) mice (at tumor onset). Trp53−/− data are the same as in Fig. 1b. c Representative image of hematoxylin and eosin staining of Trp53−/−LMP1+ tumors in SP. Asterisks and arrowheads show coagulative necrosis and myeloid infiltration, respectively. d Number of somatic mutations and total length of CNAs per sample in Trp53−/− (n = 7) and Trp53−/−LMP1+ (n = 9) tumors detected by WES. b, d Box plots show medians (lines), IQRs (boxes), and ±1.5× IQR (whiskers). *P < 0.05, **P < 0.005, ***P < 0.0005, two-sided Welch’s t-test. a, b, and d Source data are provided as a Source Data file.