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. 2024 Oct 22;9:293. doi: 10.1038/s41392-024-01986-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Single-cell transcriptome analysis reveals an increase of memory CAR-T cells while a decrease of effector/exhausted CAR-T cells after MEK inhibition. a The UMAP visualization of 35469 cells from all the samples. 8 clusters are indicated by different colors. b Dot plot illustrating the expression of the marker genes in different clusters. c PAGA analysis shows the potential developmental connectivity among all eight clusters. d, e The UMAP and bar plots show the constitution of the eight clusters in the 3 samples. f, g The UMAP and bar plots show the relative frequency of 19.28z CAR-T cells in each phase of the cell cycle. h The violin plots depict the single-cell expression of the selected genes in each cluster of the three samples. C 19.28z CAR-T, N6 Nalm-6., D DMSO, Tra trametinib. Q, quiescent. Statistical test was a two-tailed Wilcoxon test. *P< 0.05, **P <0.01, ***P < 0.001, ns: not significant