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. 2024 Oct 22;14:24266. doi: 10.1038/s41598-024-73955-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — C. perfringens strain ATCC 13124 model for degradation, import, and metabolism of hyaluronan. HysA (CPF_0394) degrades HA to unsaturated HA disaccharides on the cell surface. PTS (CPF_0401—0404) in the cytoplasmic membrane imports unsaturated HA disaccharide into the cytoplasm through phosphorylation. In the cytoplasm, UGL (CPF_0400) degrades unsaturated HA disaccharides to unsaturated uronic acid and phosphorylated amino sugar. DHU, nonenzymatically converted from unsaturated uronic acid, is metabolized by KduI (CPF_0395 and CPF_0399) and KduD (CPF_0396). The resultant is finally metabolized into glycolysis.