Table 3.
Threshold effect analysis examining the relationship between inflammatory markers and BTMs.
| NLR, Model 3a | MLR, Model 3b | PLR, Model 3c | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PINP β (95% CI) |
P-value | β-CTX β (95% CI) |
P-value | PINP β (95% CI) |
P-value | β-CTX β (95% CI) |
P-value | PINP β (95% CI) |
P-value | β-CTX β (95% CI) |
P-value | |
| Model Ad | ||||||||||||
| One line slope | -1.1788 (-1.7230, -0.6345) | < 0.0001 | -0.0104 (-0.0145, -0.0062) | < 0.0001 | -17.4523 (-27.7335, -7.1710) | 0.0009 | -0.1327 (-0.2211, -0.0443) | 0.0034 | 0.0326 (0.0007, 0.0645) | 0.0458 | 0.0003 (0.0001, 0.0006) | 0.0204 |
| Model Be | ||||||||||||
| Turning point (K) | 6 | 7.1625 | 0.1364 | 0.8226 | 244.2857 | 311.6667 | ||||||
| < K | -5.6203 (-7.3378, -3.9028) | < 0.0001 | -0.0336 (-0.0442, -0.0230) | < 0.0001 | 202.4161 (20.1683, 384.6639) | 0.0299 | -0.2185 (-0.3415, -0.0954) | 0.0005 | 0.0470 (-0.0059, 0.1000) | 0.0823 | 0.0002 (-0.0001, 0.0006) | 0.2229 |
| > K | 0.1640 (-0.5633, 0.8912) | 0.6587 | 0.0001 (-0.0059, 0.0062) | 0.9640 | -20.5459 (-31.1007, -9.9910) | 0.0002 | 0.0472 (-0.1533, 0.2477) | 0.6446 | 0.0141 (-0.0488, 0.0769) | 0.6615 | 0.0005 (-0.0002, 0.0013) | 0.1478 |
| Slope 2-Slope 1 | 5.7843 (3.6585, 7.9101) | < 0.0001 | 0.0338 (0.0195, 0.0480) | < 0.0001 | -222.9620 (-407.4822, -38.4418) | 0.0182 | 0.2657 (-0.0002, 0.5315) | 0.0506 | -0.0330 (-0.1294, 0.0634) | 0.5029 | 0.0003 (-0.0007, 0.0013) | 0.5282 |
| LRTf | < 0.001 | < 0.001 | 0.017 | 0.048 | 0.495 | 0.521 | ||||||
NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; PLR, plateletto-lymphocyte ratio; P1NP, procollagen type 1 N-terminal propeptide; β-CTX, β-C-terminal telopeptide of type I collagen; CI, confidence interval; BMI, body mass index; Ca, calcium; UA, uric acid; CR, creatinine; AST, aspartate aminotransferase; UN, urea nitrogen; HDL, high density lipoprotein; LDL, low density lipoprotein; K, potassium; Mg, magnesium; Na, sodium; P, phosphorus; Apo A, apolipoprotein A; ALT, alanine aminotransferase; ASA, the score of american society of anesthesiologists.
aAdjusted for age, sex, BMI, smoking, drinking, Ca, UA, CR, AST and Monocyte.
bAdjusted for age, sex, BMI, smoking, drinking, Ca, UA, UN, CR, HDL and LDL.
cAdjusted for age, sex, BMI, smoking, drinking, K, Mg, Na, P, Fibrinogen, Neutrophil, Apo A, HDL, Homocysteine, ALT and ASA.
dLinear analysis, P-value < 0.05 indicates a linear relationship.
eNonlinear analysis.
fP-value < 0.05 means Model B is significantly different from Model A, which indicates a nonlinear relationship.