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. 2024 Oct 22;14:24875. doi: 10.1038/s41598-024-73869-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — Morphology of patterned cortical neurons on MEAs and expression of the molecular targets of AD drugs in hiPSC-derived cortical neurons. Phase images of hiPSC-derived cortical neurons distributed on patterns aligned with MEA electrodes (A,B,E), scale bar = 100 μm. (C,D,F,G,H) Immunocytochemistry of hiPSC-derived cortical neurons utilizing antibodies specific to target proteins relevant for AD drugs revealed the cells expressed all markers evaluated: Fyn (green in C), nAChR (red in D), PDE4 (green in F), AChE (green in G), NMDR (green in H). Neurons were co-stained with the neuronal marker MAP2 and Dapi in all these images. Scale bar 50 μm.