Monday, November 13th
Time	Session/topic	Speaker/moderator
8:00–8:30	Breakfast & Registration (Lobby)
Session 1: Welcome, highlights, and opening keynote
8:30–8:45	Welcome and opening address	Emily Erbelding Mike Ison
8:45–9:30	Opening keynote	Christopher Chiu
Session 2: Use cases for CHIVIM and regulatory and ethical considerations Session 2 co‐moderators: Julie Schafer, Joe Bresee Product developer and research needs for evaluating vaccines and therapeutics Use of CHIVIM for evaluating pandemic and universal vaccines Selection of appropriate participants and CHIVIM in broader risk groups (e.g., older adults) Regulatory and ethical considerations Specific issues associated with use of data in low‐ and middle‐income countries
9:30–10:30	Panel discussion 1. Industry perspectives	Sean Tucker Raffael Nachbagauer Vivek Shinde Pamuk Bilsel
10:30–11:00	Coffee break and group photo
11:00–11:35	Short talks: Regulatory and ethical considerations	Jerry Weir Josh Morrison Claudia Emerson
11:35–12:00	Panel discussion 2. Regulatory and ethical considerations	Jerry Weir Marco Cavaleri Josh Morrison Claudia Emerson
12:00–13:00	Lunch break
Session 3: Innovation of CHIVIM Session 3 co‐moderators: Chelsea Lane, Diane Post New delivery approaches Use of CHIVIM for assessing transmission and transmission blocking New technologies (e.g., viral detection from breath and air) Mucosal sampling and assays Innate immune screening and susceptibility to infection
13:00–13:15	Exposure route effects outcome in viral disease: Case study of COVID‐19 animal model development	Chad Roy
13:15–13:30	Modeling influenza virus transmission using controlled infection: Challenges and opportunities	Anice Lowen
13:30–13:45	Evaluating modes of influenza infection: RCT design, results, implications, and ongoing trial	Don Milton
13:45–14:00	Collecting viral emissions from the air and environment after human challenge	Anika Singanayagam
14:00–14:15	Compartmentalization of the mucosal antibody response to respiratory infection: A call‐to‐arms for mucosal antibodies	Felicity Liew
14:15–14:30	Detecting antigen‐specific T cells in the upper respiratory tract using minimally‐invasive sampling	Simon Jochems
14:30–14:45	Systems‐level view of the nasal mucosa during viral infection	Samuel Kazer
14:45–15:10	Coffee break
15:10–16:10	Panel discussion and audience comments/questions	Session #3 presenters
16:10–16:30	Day 1 takeaway: Conferences IO feedback from all participants	Diane Post, Chelsea Lane
16:30–16:45	Recap of Day 1	Vivien Dugan
17:00	Adjourn (Day 1)

Tuesday, November 14th
Time	Session/topic	Speaker/moderator
8:00–8:30	Breakfast (lobby)
8:30–8:40	Plan for Day 2	Mike Ison
Session 4: CHIVIM networks and standardization Session 4 co‐moderators: Catherine Luke, Chris Roberts, Dave Wentworth Data presentations from CHIVIM networks and their capabilities Standardization of strain selection and manufacturing (and CHIVIM reagent access) Standardization of CHIVIM clinical protocols (e.g., routes of challenge administration and delivery methods, definition of disease) Standardization of traditional serologic and cellular adaptive immune response assays
8:40–9:05	NIAID collaborative influenza vaccine innovation centers and infectious diseases clinical research consortium studies	Kathy Neuzil
9:05–9:20	Human influenza challenge models: Meeting the demands of the future	Matt Memoli
9:20–9:40	CHIVIM plans at the Doherty Institute in Australia	Kanta Subbarao
9:40–10:40	Panel discussion 1. Standardization of strain selection and manufacturing and CHIVIM reagent access	Dave Wentworth Matt Memoli Richard Webby Derek Smith Florian Krammer Dan Stoughton Andrew Catchpole
10:40–11:00	Coffee break
11:00–12:00	Panel discussion 2. Standardization of CHIVIM clinical trial protocols	Kathy Neuzil Christopher Chiu Dan Hoft Chris Woods Matt Memoli
12:00–13:00	Lunch
13:00–13:40	Panel discussion 3. Standardization of immunological assays	Kanta Subbarao Othmar Engelhardt Rebecca Cox
Session 5: Defining success using CHIVIM in vaccine development Session 5 co‐moderators: Mike Ison, Marianne Stanford
13:40–14:20	Panel discussion	Fred Hayden Hanna Golding Marco Cavaleri Andrew Catchpole Sean Tucker Jeff Taubenberger Justin Ortiz
14:20–14:40	Day 2 takeaway: Conferences IO feedback from all participants	Mike Ison Marianne Stanford
14:40–14:55	Recap of Day 2	Catherine Luke
14:55–15:00	Closing and thanks	Catherine Luke Chelsea Lane