Figure 1.

Oral antibiotics used to treat mild to moderate skin and soft tissue infections in adults in the emergency department setting without systemic signs of infection (eg, fever, tachycardia, tachypnea, increased white blood cells). Mild purulent infections without systemic signs of infection may be treated with incision and drainage without antibiotics. MSSA indicates methicillin-sensitive Staphylococcus aureus; MRSA, methicillin-resistant Staphylococcus aureus; penicillin VK, penicillin V potassium; TMP/SMX, trimethoprim/sulfamethoxazole. Adapted, with permission, from LaPlante K. Providence Veterans Affairs Medical Center Antimicrobial Guide Empiric Therapy, 5th edition; and reference 22.