Figure 3.

Identification of specific metabolites of DLM. a) Summary of precursor ions present in extracts of DLM‐ or ¹³C₆‐DLM‐treated Mtb. Original precursor ion spectra of the extracts are shown in Figure S3 (Supporting Information). b) Relative abundance of the corresponding metabolites from the indicated strains in (a). Data are expressed as the mean ± SD of three cultures. Statistical significance was assessed by one‐way ANOVA with Tukey's multiple comparison test. *p < 0.05; ****p < 0.0001. c) Model of DLM metabolic pathways in mycobacteria based on the findings from this and previous studies.^{[ 20} , ^{24 ]} Metabolites circled by dotted lines might not have antimycobacterial activity.^{[ 9} , ²⁰ , ^{24 ]}