TABLE 5.
Kaplan–Meier analysis of 5‐year OS (%) among 513 cT4b tumors undergoing surgical resection + additional therapy.
| NSM | PSM | p‐value | |
|---|---|---|---|
| Overall | 63.9 | 56.3 | .059 |
| Histology | |||
| Adenocarcinoma | 54.5 | 66.2 | .820 |
| Adenoid cystic carcinoma | 70.6 | 69.0 | .842 |
| Neuroendocrine carcinoma | 68.8 | 54.2 | .332 |
| Mucoepidermoid carcinoma | 66.7 | ‐ | .069 |
| Melanoma | 42.9 | 36.0 | .511 |
| Esthesioneuroblastoma | 87.5 | 81.3 | .290 |
| Undifferentiated carcinoma | 64.2 | 25.0 | .001 |
| Primary site | |||
| Nasal cavity | 78.4 | 55.2 | .009 |
| Maxillary sinus | 60.0 | 61.4 | .589 |
| Ethmoid sinus | 54.3 | 51.4 | .635 |
| Frontal sinus | 60.0 | 50.0 | .743 |
| Sphenoid sinus | 66.7 | 69.2 | .882 |
| Sinus: overlapping, unspecified | 50.0 | 50.0 | .901 |
| Nasopharynx | 71.4 | 100.0 | .728 |
| Clinical nodal metastasis | |||
| No | 70.3 | 58.3 | .011 |
| Yes | 40.0 | 44.8 | .717 |
| Additional therapy | |||
| Chemotherapy alone | 61.2 | 57.6 | .644 |
| RT alone | 40.0 | 42.9 | .666 |
| CRT | 67.3 | 56.1 | .043 |
| Therapy sequence | |||
| Adjuvant | 64.7 | 57.1 | .123 |
| Neoadjuvant | 63.6 | 51.7 | .136 |
Abbreviations: CRT, chemoradiotherapy; NSM, negative surgical margins; OS, overall survival; PSM, positive surgical margins; RT, radiotherapy. Bolded values indicate statistically significant results (p<0.05).