Table 3.
Significant interactions of time‐updated potassium categories by time‐updated estimated glomerular filtration rate
| Outcome/eGFR subgroup | HR (95% CI) | P‐value | eGFR by K+ interaction P‐value |
|---|---|---|---|
| CV death | |||
| K+ in eGFR ≥60 | |||
| <4 | 0.65 (0.34–1.22) | 0.18 | |
| 4–5 | Referent | – | |
| >5 | 0.81 (0.42–1.57) | 0.54 | |
| K+ in eGFR <60 | 0.004 | ||
| <4 | 1.98 (1.42–2.75) | <0.001 | |
| 4–5 | Referent | – | |
| >5 | 1.28 (0.94–1.73) | 0.11 | |
| All‐cause death | |||
| K+ in eGFR ≥60 | |||
| <4 | 0.94 (0.62–1.44) | 0.77 | |
| 4–5 | Referent | – | |
| >5 | 1.10 (0.69–1.74) | 0.69 | |
| K+ in eGFR <60 | 0.042 | ||
| <4 | 1.88 (1.45–2.43) | <0.001 | |
| 4–5 | Referent | – | |
| >5 | 1.06 (0.82–1.35) | 0.67 |
CI, confidence interval; CV, cardiovascular; eGFR, estimated glomerular filtration rate (mL/min/1.73 m2); HR, hazard ratio; K+, serum potassium (mmol/L).