Table 3.

Overall performance test of ColonFlag across the studies included in the systematic review

Study	Mean ColonFlag score	AUC (95% CI)	Sensitivity (%, 95% CI)	Specificity (%, 95% CI)	PPV (%)	NPV (%)	OR (95% CI)
Kinar, 2016 10 (Israel)		0.82±0.01*		88±2*			26±5*
Kinar, 2016 10 (UK)		0.81		94±1			40±6
Kinar, 2017 14	Female=59.3		17.3				21.8 (13.8, 34.2)
	Male=46.8
Birks, 2017 16	No CRC=51.5±29.0	0.776 (0.771, 0.781)	3.91 (3.40, 4.48)	82.73 (82.68, 82.78)	8.8	99.6	26.5 (23.3, 30.2)
	CRC=79.1±19.5
Hornbrook, 2017 15		0.8 (0.79, 0.82)					34.7 (28.9, 40.4)
Ayling, 2018 21			52.4	71.3	6.3	97.6
Goshen, 2018 17			21.7				33.3 (22.6, 49.1)
Hilsden, 2018 6	56.8±18.5		8.1 (6.4, 9.8)				5.1 (2.3, 8.9)
Schneider, 2020 18		0.78 (0.77, 0.78)	35.4 (33.8, 36.7)				17.7 (16.5, 18.7)
Ayling, 2021 22			88.24 (63.56, 98.54)	71.07 (66.94, 74.94)	9.1 (95% CI, 7.47, 11.15)	99.45 (95% CI, 98.03, 99.85)
Holt, 2023 19	No CRC=56.3	0.736 (0.715, 0.759)	10		2.6	99.9	1.05 (1.047, 1.053)**
	CRC=83.8

AUC: Area Under the Curve; PPV: Positive predictive value; NPV: Negative predictive value; OR: Odds ratio;

^*Standard Deviation (SD value);

^**OR for a ColonFlag/unit increase