. 2021 Aug 30;149(12):1980–1996. doi: 10.1002/ijc.33762

TABLE 2.

The International Myeloma Working Group revised international staging system (R‐ISS) ³¹

Stage	R‐ISS	5‐year OS
I	Serum albumin >3.5 g/dL Serum β₂‐microglobulin <3.5 mg/L No high‐risk cytogenetic features Normal serum lactate dehydrogenase level	82%
II	Neither Stage I or III	62%
III	Serum β₂‐microglobulin >3.5 mg/L and high‐risk cytogenetics (t(4;14), t(14;16), del(17p)) or elevated serum lactate dehydrogenase level	40%

Stage

R‐ISS

5‐year OS

Serum albumin >3.5 g/dL

Serum β₂‐microglobulin <3.5 mg/L

No high‐risk cytogenetic features

Normal serum lactate dehydrogenase level

82%

Neither Stage I or III

62%

III

Serum β₂‐microglobulin >3.5 mg/L and high‐risk cytogenetics (t(4;14), t(14;16), del(17p)) or elevated serum lactate dehydrogenase level

40%

Abbreviation: OS, overall survival.