Fig. 2.

Widespread distribution of virus-positive cells in the tissue lesion of the patient. (A) Representative overview image of a tissue section from the abscess region stained for MPXV B6R showing widespread distribution of the MPXV B6R protein in 25× magnification. (B) Close-up of boxed region in A at 100× magnification (C) a consecutive section stained for H&E displaying the same region as in B showing severe necrosis and pronounced tissue destruction in virus-protein positive areas. (D) Transmission electron microscopy of the necrotic lesion reveils intracellular mature virus particles and single fully enveloped virus particles.