Table 3.
AUROCs and 95% CIs of LiverRisk score, FIB-4, and APRI for the diagnosis of cACLD in cohorts I and II, as well as time-dependent AUROC values of LiverRisk score, LSM, FIB-4, and APRI for the prediction of hepatic decompensation in cohort I.
| Metric | Cohort I (n = 5,897) | Cohort II (n = 1,558) | |||
|---|---|---|---|---|---|
| cACLD (≥10 kPa) | |||||
| LiverRisk score | 0.757 (0.744–0.770) | 0.790 (0.762–0.819) | |||
| FIB-4 | 0.769 (0.755–0.783) | 0.831 (0.785–0.841) | |||
| APRI |
0.747 (0.733–0.762) |
0.765 (0.734–0.797) |
|||
|
Cohort I (n = 5,897) |
|||||
|
Hepatic decompensation | |||||
| Time (years) | 1 | 2 | 3 | 4 | 5 |
| Events (n) | 28 | 60 | 79 | 102 | 115 |
| LiverRisk score | 0.778 (0.703–0.852) | 0.816 (0.772–0.860) | 0.823 (0.787–0.858) | 0.826 (0.795–0.858) | 0.832 (0.803–0.860) |
| LSM | 0.847 (0.779–0.915)∗ | 0.891 (0.855–0.927)∗ | 0.897 (0.865–0.928)∗ | 0.892 (0.865–0.918)∗ | 0.901 (0.877–0.925)∗ |
| FIB-4 | 0.898 (0.854–0.943)∗ | 0.910 (0.874–0.946)∗ | 0.913 (0.883-0.942)∗ | 0.898 (0.868–0.928)∗ | 0.901 (0.872–0.929)∗ |
| APRI | 0.856 (0.802–0.909) | 0.855 (0.814–0.895) | 0.862 (0.829–0.894) | 0.850 (0.819–0.880) | 0.853 (0.824–0.882) |
ROC analysis, time-dependent ROC analysis, and comparison according to Blanche et al.15 Level of significance after multiplicity correction: p <0.05.
AUROC, area under the receiver operator characteristics curve; APRI, aspartate aminotransferase-to-platelet ratio index; cACLD, compensated advanced chronic liver disease; FIB-4, fibrosis-4; LSM, liver stiffness measurement; ROC, receiver operator characteristics.
Statistically significant difference in AUROC compared with the AUROC of LiverRisk score (according to Blanche et al.15).