Table 1.
Baseline characteristics and factors included in the final model: a comparison between the training and the validation groups.
| Training group (n = 23,770) | Test group (n = 5943) | |
|---|---|---|
| Recipient factors | ||
| Cause of renal failure: n (%) | ||
| Diabetes/hypertension: | 5463 (22.98%) | 1340 (22.55%) |
| Glomerulonephritis/vasculitis: | 4768 (20.06%) | 1175 (19.77%) |
| Cancer: | 127 (0.53%) | 39 (0.66%) |
| Congenital: | 4707 (19.80%) | 1148 (19.32%) |
| Unspecified: | 8566 (36.04%) | 2211 (37.20%) |
| Vascular: | 139 (0.58%) | 30 (0.50%) |
| Recipient age: mean (standard deviation): | 51.18 (13.50) | 51.15 (13.40) |
| Pediatric at registration: n (%) | ||
| -No: | 18,958 (79.76%) | 4768 (80.23%) |
| -Unknown: | 4728 (19.89%) | 1154 (19.42%) |
| -Yes: | 84 (0.35%) | 21 (0.35%) |
| Recipient weight in kg: mean (standard deviation): | 77.24 (21.97) | 77.43 (20.86) |
| -Missing data (n%): | 93 (<1%) | 257 (4.32%) |
| Recipient height in cm: mean (standard deviation): | 169.59 (22.20) | 170.63 (31.65) |
| -Missing data (n%): | 5189 (21.80%) | 1256 (21.13%) |
| Recipient body mass index in kg/m2: mean (standard deviation): | 26.73 (4.78) | 26.70 (4.72) |
| -Missing data (n%): | 5316 (22.36%) | 1283 (21.58%) |
| Recipient ethnicity: n (%) | ||
| White: | 17,221 (72.45%) | 4305 (72.44%) |
| Asian: | 3539 (14.89%) | 869 (14.84%) |
| Black: | 2035 (8.56%) | 515 (8.67%) |
| Other: | 775 (3.26%) | 200 (3.37%) |
| Not reported: | 200 (0.84%) | 54 (0.91%) |
| Waiting time in days: mean (standard deviation): | 1005.717 (857.78) | 979.74 (805.95) |
| -Missing data (n%): | 118 (<1%) | 24 (<1%) |
| Dialysis at registration: n (%): | ||
| Hemodialysis: | 11,468 (48.37%) | 2861 (48.28%) |
| Peritoneal dialysis: | 4069 (17.16%) | 995 (16.79%) |
| Not on dialysis: | 8018 (33.82%) | 2033 (34.31%) |
| Unknown: | 153 (0.65%) | 37 (0.63%) |
| Graft number: n (%) | ||
| One: | 20,401 (85.82%) | 5154 (86.72%) |
| Two: | 2834 (11.92%) | 678 (11.41%) |
| Three: | 463 (1.95%) | 103 (1.73%) |
| More than three: | 70 (0.31%) | 8 (0.13%) |
| Donor factors | ||
| Donor age: mean (standard deviation): | 49.41 (16.14%) | 49.77 (15.99) |
| Donor height in cm: mean (standard deviation): | 170.30 (11.78) | 170.18 (12.03) |
| Donor weight in kg: mean (standard deviation): -Missing data (n%): |
78.04 (18.65) 22 (<1%) |
77.86 (18.53) 8 (<1%) |
| Donor body mass index in kg/m2: mean (standard deviation): | 26.66 (5.44) | 26.62 (5.47) |
| -Missing data (n%): | 185 (<1%) | 45 (<1%) |
| Donor urine output in the last 24 h in milliliters: mean (standard deviation): | 2800.30 (1678.61) | 2785.45 (1629.68) |
| -Missing data (n%): | 8502 (35.76%) | 2131 (35.85%) |
| Donor urine output in the last hour in milliliters: mean (standard deviation): | 112.68 (111.10) | 111.68 (119.35) |
| -Missing data (n%): | 518 (2.1%) | 140 (2.3%) |
| Donor creatinine in mmole/litre: mean (standard deviation): | 81.38 (55.18) | 81.83 (56.58) |
| -Missing data (n%): | 1091 (4.5%) | 260 (4.3%) |
| Donor history of hypertension: n (%) | ||
| No: | 16,987 (71.63%) | 4205 (70.97%) |
| Yes: | 6300 (26.57%) | 1620 (27.34%) |
| Unknown: | 483 (2%) | 118 (1.69%) |
| Donor history of smoking: n (%) | ||
| No: | 10,552 (44.50%) | 2633 (44.44%) |
| Yes: | 12,984 (54.75%) | 3254 (54.92%) |
| Unknown: | 178 (0.75%) | 38 (0.64%) |
| Donor amount of smoking: mean (standard deviation) | 16.36 (12.64) | 16.33 (12.46) |
| Transplant factors | ||
| HLA A mismatch: n (%) | ||
| 0: | 4679 (19.69%) | 1105 (18.59%) |
| 1: | 11,496 (48.38%) | 2912 (49%) |
| 2: | 7538 (31.72%) | 1916 (32.24%) |
| Unknown: | 57 (0.21%) | 10 (0.17%) |
| HLA B mismatch: n (%) | ||
| 0: | 3906 (16.44%) | 910 (15.31%) |
| 1: | 15,433 (64.95%) | 3920 (65.96%) |
| 2: | 4,374 (18.41%) | 1103 (18.56%) |
| Unknown: | 57 (0.21%) | 10 (0.17%) |
| HLA DR mismatch: n (%) | ||
| 0: | 10,097 (42.49%) | 2528 (42.54%) |
| 1: | 11,605 (48.84%) | 2883 (48.51%) |
| 2: | 2011 (8.46%) | 522 (8.78%) |
| Unknown: | 57 (0.21%) | 10 (0.17%) |
| Match points: mean (standard deviation): | 6.01 (2.37) | 5.97 (2.38) |
| -Missing data (n%): | 162 (<1%) | 30 (<1%) |
| Matchability band: mean (standard deviation): | 103.44 (105.21) | 105.63 (105.84) |
| -Missing data (n%): | 162 (<1%) | 30 (<1%) |
| Calculated reaction frequency: mean (standard deviation): | 21.88 (34.25%) | 20.58 (19.74%) |