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Mitochondrial antisense RNA degradosome-dependent degradation. GRSF1 binds to antisense mtRNA and melts G4 structures. Then, SUV3 helps to dissociate GRSF1 from RNA and unwinds double-stranded RNA structures, which enables degradation of the substrate by PNPase, and 4-5 nts fragments are generated. In the final stage, REXO2 removes short oligonucleotides. Created with BioRender.com.
