TABLE 2.
Demographic and clinical characteristics of the sample with stratification based on age, APOE ε4, and education group.
| Parameter |
Age < 55 N = 169 |
Age ≥55 N = 254 |
APOE ε4 N = 95 |
Non‐APOE ε4 N = 315 |
>College degree N = 275 |
≥College degree N = 148 |
|---|---|---|---|---|---|---|
| Age, years | 48 ± 5 | 64 ± 7 | 57 ± 10 | 57 ± 10 | 56 ± 10 | 59 ± 9 |
| Female, n (%) | 87 (52%) | 126 (50%) | 48 (51%) | 160 (51%) | 142 (52%) | 71 (48%) |
|
Race and ethnicity, n (%) Non‐Hispanic White Unknown |
169 (100%) 0 (0%) |
252 (99%) 2 (1%) |
95 (100%) 0 (0%) |
313 (99%) 2 (1%) |
273 (99%) 2 (1%) |
148 (100%) 0 (%) |
|
Education, n (%) No college degree College degree or higher |
46 (27%) 123 (73%) |
102 (40%) 152 (60%) |
27 (28%) 68 (72%) |
115 (36%) 200 (64%) |
275 (100%) 0 (0%) |
0 (0%) 148 (100%) |
| APOE ε4 allele, n (%) | 42 (26%) | 53 (22%) | 95 (100%) | 0 (0%) | 68 (25%) | 27 (19%) |
| Interval between cognitive testing and PET Imaging, years | 0.2 ± 0.2 | 0.2 ± 0.2 | 0.2 ± 0.2 | 0.2 ± 0.2 | 0.2 ± 0.3 | 0.2 ± 0.1 |
| Verbal memory a | 0.17 ± 0.99 | −0.11 ± 0.99 | −0.06 ± 1.04 | 0.00 ± 0.98 | 0.19 ± 0.96 | −0.35 ± 0.98 |
| Visual memory a | 0.23 ± 0.92 | −0.15 ± 1.02 | 0.01 ± 1.09 | 0.00 ± 0.97 | 0.15 ± 0.98 | −0.28 ± 0.98 |
| Attention/Executive a | 0.29 ± 0.92 | −0.20 ± 1.01 | −0.14 ± 1.02 | 0.04 ± 0.98 | 0.16 ± 0.93 | −0.31 ± 1.06 |
| Language a | 0.01 ± 1.00 | 0.00 ± 1.00 | 0.11 ± 1.02 | −0.02 ± 0.99 | 0.16 ± 0.98 | −0.31 ± 0.96 |
| Visuospatial a | 0.24 ± 0.98 | −0.16 ± 0.98 | −0.04 ± 1.03 | 0.00 ± 0.97 | 0.04 ± 0.98 | −0.08 ± 1.04 |
| Global cognitio a | 0.29 ± 0.93 | −0.19 ± 1.00 | −0.01 ± 1.05 | −0.01 ± 0.98 | 0.27 ± 0.89 | −0.50 ± 1.00 |
|
Aβ Centiloid, n (%) <20 20‐39 ≥40 |
(N = 169) 165 (98%) 0 (0%) 4 (2%) |
(N = 234) 215 (92%) 14 (6%) 5 (2%) |
(N = 87) 77 (89%) 8 (9%) 2 (2%) |
(N = 303) 292 (97%) 4 (1%) 7 (2%) |
(N = 260) 250 (96%) 6 (2%) 4 (2%) |
(N = 143) 130 (91%) 8 (6%) 5 (3%) |
| Global Aβ, DVR | 1.04 ± 0.04 | 1.11 ± 0.13 | 1.11 ± 0.12 | 1.07 ± 0.11 | 1.08 ± 0.12 | 1.08 ± 0.09 |
| Entorhinal tau, SUVR | 1.05 ± 0.07 | 1.06 ± 0.11 | 1.08 ± 0.11 | 1.05 ± 0.09 | 1.06 ± 0.09 | 1.04 ± 0.11 |
| Rhinal tau, SUVR | 1.08 ± 0.08 | 1.11 ± 0.12 | 1.12 ± 0.12 | 1.09 ± 0.10 | 1.05 ± 0.09 | 1.08 ± 0.12 |
| Inferior temporal tau, SUVR | 1.12 ± 0.06 | 1.16 ± 0.09 | 1.15 ± 0.09 | 1.14 ± 0.08 | 1.14 ± 0.08 | 1.13 ± 0.08 |
| Middle temporal tau, SUVR | 1.07 ± 0.07 | 1.12 ± 0.09 | 1.11 ± .09 | 1.09 ± 0.08 | 1.10 ± 0.08 | 1.09 ± 0.08 |
| Fusiform tau, SUVR | 1.13 ± 0.06 | 1.15 ± 0.08 | 1.15 ± 0.09 | 1.13 ± 0.07 | 1.14 ± 0.07 | 1.13 ± 0.09 |
Note: Values represent mean ± standard deviation unless otherwise noted.
Abbreviations: Aβ, amyloid beta, APOE, apolipoprotein E, DVR, distribution volume ratio, PET, positron emission tomography, SUVR, standardized uptake value ratio.
Values standardized to z‐scores.