. 2024 Jul 5;20(9):6183–6204. doi: 10.1002/alz.14100

TABLE 4.

PACC3 mixed‐effects output (Aim 3).

	1(predictor = p‐tau217)			2(predictor = Aβ42/40)			3(predictor = p‐tau181)			4(predictor = p‐tau231)			5(predictor = GFAP)			6(predictor = Nfl)
Predictors	Estimates	CI	p	Estimates	CI	p	Estimates	CI	p	Estimates	CI	p	Estimates	CI	p	Estimates	CI	p
Intercept	0.00	−0.14 to −0.14	0.978	−0.01	−0.15 to −0.12	0.838	−0.00	−0.14 to −0.13	0.944	−0.01	−0.15 to −0.13	0.921	−0.01	−0.15 to −0.13	0.883	−0.00	−0.14 to −0.14	0.989
Male	−0.52	−0.64 to −0.39	<0.001	−0.53	−0.65 to −0.40	<0.001	−0.51	−0.63 to −0.39	<0.001	−0.53	−0.65 to −0.40	<0.001	−0.52	−0.65 to −0.40	<0.001	−0.53	−0.65 to −0.41	<0.001
No BA	−0.20	−0.33 to −0.06	0.005	−0.19	−0.33 to −0.05	0.008	−0.19	−0.33 to −0.06	0.006	−0.19	−0.33 to −0.05	0.006	−0.19	−0.33 to −0.05	0.007	−0.20	−0.34 to −0.06	0.006
Practice	0.09	0.07 to −0.12	<0.001	0.10	0.07 to −0.12	<0.001	0.09	0.07 to −0.12	<0.001	0.10	0.07 to −0.12	<0.001	0.10	0.07 to −0.12	<0.001	0.09	0.06 to −0.12	<0.001
WRAT3	0.02	0.01 to −0.03	<0.001	0.02	0.01 to −0.03	<0.001	0.02	0.01 to −0.03	<0.001	0.02	0.01 to −0.03	<0.001	0.02	0.01 to −0.03	<0.001	0.02	0.01 to −0.03	<0.001
c60age	−0.04	−0.05 to −0.03	<0.001	−0.04	−0.05 to −0.03	<0.001	−0.04	−0.05 to −0.03	<0.001	−0.04	−0.05 to −0.03	<0.001	−0.04	−0.05 to −0.03	<0.001	−0.04	−0.05 to −0.03	<0.001
c60age²	−0.00	−0.00 to −0.00	0.077	−0.00	−0.00 to −0.00	0.015	−0.00	−0.00 to −0.00	0.037	−0.00	−0.00 to −0.00	0.029	−0.00	−0.00 to −0.00	0.015	−0.00	−0.00 to −0.00	0.005
c60age³	−0.00	−0.00 to −0.00	<0.001	−0.00	−0.00 to −0.00	<0.001	−0.00	−0.00 to −0.00	<0.001	−0.00	−0.00 to −0.00	<0.001	−0.00	−0.00 to −0.00	0.009	−0.00	−0.00 to −0.00	<0.001
z p‐tau217	−0.00	−0.03 to −0.03	0.875
c60age × z p‐tau217	−0.01	−0.01 to −0.00	0.002
z p‐tau217 × c60age²	−0.00	−0.00 to −0.00	0.041
z ab4240				−0.01	−0.07 to −0.05	0.739
c60age × z ab4240				0.01	0.00 to −0.01	0.016
z p‐tau181							−0.03	−0.07 to −0.01	0.199
c60age × z p‐tau181							−0.01	−0.01 to −0.00	<0.001
z p‐tau231										−0.00	−0.05 to −0.05	0.914
c60age × z p‐tau231										−0.00	−0.01 to −0.00	0.034
z GFAP													0.02	−0.03 to −0.08	0.356
c60age × z GFAP													−0.00	−0.01 to −0.00	0.544
z GFAP × c60age²													−0.00	−0.00 to −0.00	0.001
z NfL																−0.02	−0.09 to −0.04	0.464
Random effects
σ²	0.11			0.11			0.11			0.11			0.11			0.11
τ₀₀	0.29_Reggieid			0.29_Reggieid			0.28_Reggieid			0.29_Reggieid			0.29_Reggieid			0.28_Reggieid
τ₁₁	0.00_{Reggieid.c60age}			0.00_{Reggieid.c60age}			0.00_{Reggieid.c60age}			0.00_{Reggieid.c60age}			0.00_{Reggieid.c60age}			0.00_{Reggieid.c60age}
ρ₀₁	−0.00_Reggieid			−0.00_Reggieid			−0.04_Reggieid			−0.02_Reggieid			0.02_Reggieid			−0.01_Reggieid
ICC	0.76			0.76			0.76			0.76			0.76			0.76
N	412_Reggieid			412_Reggieid			408_Reggieid			412_Reggieid			412_Reggieid			412_Reggieid
Observations	1973			1973			1951			1973			1973			1973
Marginal R ²/conditional R ²	0.352/0.842			0.333/0.842			0.349/0.841			0.333/0.841			0.339/0.841			0.332/0.841
AICc	2600.4			2631.2			2594.6^a			2632.2			2609.6			2634.4
$Δ$ AICc	−32.5			−1.73			−13.5			−0.66			−23.3			1.48

Notes: Base model includes the age fixed effects up to cubic polynomial (retaining highest order significant term and lower order terms; centered at age 60 (c60)), random effects and covariates: sex, practice, education (BA bachelors degree), Wide Range Achievement Test‐III (WRAT3) reading score. The change in Akaike information criterion $Δ$ AICc is calculated relative to the base model; negative numbers indicate a better fit in the expanded model. Bold values are statistically significant. ICC is the intraclass correlation coefficient; Reggieid is the person‐level study number.

^{^a}

There are four missing baseline p‐tau181. The smallest AICc is Model 1, 2575.9 (ΔAICc = −32.3); followed by Model 5, 2584.7 (ΔAICc = −23.5); and Model 3, 2594.6 (ΔAICc = −13.5) when we compared the model results in the same data sets.