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Voxelwise associations between white matter hyperintensities and gray matter volume. Results of voxelwise regression model showing gray matter volume negatively associated with WMH in (A) whole DS cohort and (B) aDS and (C) sDS subgroups. The significance of the results (T values) is shown using a threshold pFWE < 0.05. Abbreviations: aDS, asymptomatic Down syndrome; DS, Down syndrome; sDS, symptomatic Down syndrome; FWE, family‐wise error.
