TABLE 3.
Adverse events in each therapy group.
| Culture‐based tailored therapy | Empirical concomitant therapy | p value | |
|---|---|---|---|
| (n = 229) | (n = 75) | ||
| Influence on daily activity | <0.001 | ||
| None | 124 (54.1) | 21 (28.0) | |
| Mild | 77 (33.6) | 28 (37.3) | |
| Moderate | 28 (12.2) | 26 (34.7) | |
| Taste alteration (%) | 49 (21.4) | 34 (45.3) | <0.001 |
| Grade 2 | 10 | 16 | |
| Diarrhea (%) | 40 (17.5) | 17 (22.7) | 0.317 |
| Grade 2 | 12 | 7 | |
| Constipation (%) | 3 (1.3) | 6 (8.0) | 0.008 |
| Grade 2 | 0 | 3 | |
| Abdominal pain (%) | 11 (4.8) | 8 (10.7) | 0.095 |
| Grade 2 | 3 | 3 | |
| Nausea (%) | 20 (8.7) | 9 (12.0) | 0.403 |
| Grade 2 | 3 | 4 | |
| Vomiting (%) | 4 (1.7) | 2 (2.7) | 0.639 |
| Grade 2 | 1 | 1 | |
| Bloating (%) | 5 (2.2) | 4 (5.3) | 0.232 |
| Grade 2 | 1 | 0 | |
| Belching (%) | 0 (0.0) | 2 (2.7) | 0.060 |
| Grade 2 | 0 | 0 | |
| Acid reflux (%) | 4 (1.7) | 4 (5.3) | 0.106 |
| Grade 2 | 0 | 1 | |
| Chest distress (%) | 3 (1.3) | 3 (4.0) | 0.162 |
| Grade 2 | 2 | 2 | |
| Dizziness (%) | 7 (3.1) | 11 (14.7) | 0.001 |
| Grade 2 | 3 | 6 | |
| Fatigue (%) | 10 (4.4) | 8 (10.7) | 0.086 |
| Grade 2 | 3 | 5 | |
| Skin rash (%) | 5 (2.2) | 0 (0.0) | 0.338 |
| Grade 2 | 0 | 0 |