TABLE 1.
Demographics: Data from 17 CHARGE cohorts were included in our meta‐analysis, as were the UKBB, ADGC, and EADB for the replication of our VaD results in European ancestry.
| Study | N/Control | ACD | VaD | Percentage VaD | Age (mean) | Sex, % (percentage female) |
|---|---|---|---|---|---|---|
| European ancestry | ||||||
| 3C | 6475 | 808 | 162 | 20.1 | 74.2 | 61.0 |
| AGES | 5656 | 1501 | 118 | 7.9 | 76.1 | 61.0 |
| ARIC | 3145 | 165 | 36 | 21.8 | 75.5 | 60.0 |
| ASPREE | 12,480 | 319 | NA | NA | 75.0 | 55.0 |
| CHS | 2169 | 508 | 156 | 30.7 | 74.9 | 61.5 |
| FVG | 804 | 73 | NA | NA | 58.2 | 58.3 |
| FHS | 4175 | 679 | 167 | 24.5 | 54.6 | 54.3 |
| GRACE | 12,599 | 7516 | 1953 | 26.0 | 78.8 | 68.2 |
| GREAT‐AGE | 1504 | 138 | 7 | 5.1 | 73.7 | 50.3 |
| HUNT | 69,633 | 3982 | 681 | 17.1 | 67.7 | 57.4 |
| MEMENTO | 2050 | 263 | 36 | 13.7 | ||
| MYHAT | 865 | 50 | NA | NA | 83.7 | 59.5 |
| ROSMAP | 1335 | 626 | NA | NA | 79.8 | 69.7 |
| RS (1,2,3) | 11,390 | 1715 | 178 | 10.4 | 63.6 | 56.8 |
| ADGC‐NAJ‐2011 | 15,675 | 8309 | NA | NA | 75.4 | 59.5 |
| UKBB | 314,278 | 17,008 | 332 | NA | 66.1 | 63.1 |
| Total European | 466,606 | 44,009 | 3892 | |||
| African ancestry | ||||||
| ARIC | 905 | 101 | 31 | 30.7 | 75.5 | 60.0 |
| CHS | 514 | 194 | 65 | 33.5 | 74.9 | 61.5 |
| ADGC‐Reitz (2013) | 5896 | 1968 | NA | NA | 80.5 | 63.9 |
| Total African | 7315 | 2263 | 96 | |||
| Asian ancestry | ||||||
| HKOS | 2373 | 349 | 66 | 18.9 | 60.1 | 67.9 |
| Harmonization | 385 | 153 | 49 | 32.0 | 73.6 | 55.0 |
| Total Asian | 2758 | 502 | 115 | |||
| Hispanic ancestry | ||||||
| SALSA | 1271 | 128 | 35 | 27.3 | 68.9 | 58.6 |
| Total Stage 1 for ACD and VaD | 477,950 | 46,902 | 4138 | |||
| Replication of VaD results in EADB | ||||||
| EADB | 275,745 | NA | 4,564 | |||
| Total | 753,695 | 46,902 | 8702 | |||
Note: Overall, 800,597 individuals were included in this study, accounting for 46,902 and 8702 cases of ACD and VaD, respectively. For UKBB, we used the proxy‐AD (familial AD) for ACD analysis and assessed VaD cases using ICD10 codes (see Methods). We also used ADGC‐NAJ‐201118 and ADGC‐Reitz‐201319 for ACD in European and African ancestry, respectively, to avoid overlap with CHARGE samples. We subsequently replicated our VaD results in EADB.
Abbreviations: ACD, all‐cause dementia; ADGC, Alzheimer's Disease Genetics Consortium; EADB, the European Alzheimer Disease Biobank; UKBB, the UK Biobank.