TABLE 2.

Genome‐wide significant (p < 5 × 10⁻⁸) and suggestive (p < 1 × 10⁻⁶) variants associated with all‐cause dementia in European populations.

rsID	Nearest gene	CHR	POS	EA/NEA	EAF	BETA	p value	HetISq	HetChiSq	HetPVal
rs429358	APOE	19q13.32	45411941	C/T	0.1515	1.1728	6.87E‐305	98.3	1104.478	2.534E‐222
rs4663105	BIN1	2q14.3	127891427	C/A	0.4151	0.156	5.856E‐34	63.4	51.892	0.00006868
rs12453	MS4A6A	11q12.2	59945745	C/T	0.3998	−0.0933	1.116E‐16	13.2	23.037	0.287
rs10792832	PICALM	11q14.2	85867875	A/G	0.3585	−0.0857	8.234E‐14	61.8	52.41	0.0000992
rs10948367	CD2AP	6p12.3	47585615	G/A	0.2712	0.0886	4.041E‐13	4.2	20.88	0.4042
rs4295	ACE	17q23.3	61556298	C/G	0.3897	−0.0784	1.014E‐11	10.8	22.43	0.3176
rs4844610	CR1	1q32.2	207802552	A/C	0.1846	0.0961	1.245E‐11	71.4	66.468	3.519E‐07
rs2906644	PILRB	7q22.1	99956290	G/C	0.1294	−0.1016	7.627E‐09	0	8.219	0.9616
rs3764650	ABCA7	19p13.3	1046520	G/T	0.0957	0.1141	1.125E‐08	35	24.604	0.07712
rs9323877	SLC24A4	14q32.12	92934269	G/A	0.2521	0.0699	3.804E‐08	0	19.881	0.4654
rs1532278	CLU	8p21.1	27466315	T/C	0.3819	−0.0629	6.262E‐08	66.2	59.185	9.516E‐06
rs7912495	USP6NL	10p14	11718713	G/A	0.4612	0.0684	6.774E‐08	0	15.343	0.7006
rs17125924	FERMT2	14q22.1	53391680	G/A	0.0928	0.1009	9.38E‐08	2.6	19.508	0.4247
rs11767557	EPHA1	7q34	143109139	C/T	0.1998	−0.0742	9.721E‐08	31.2	29.052	0.08675
rs1854554	SEMA4D	9q22.2	92155871	A/G	0.409	0.0598	1.096E‐07	4	20.83	0.4072
rs7118826	ANO3	11p14.2	26195535	G/C	0.4585	0.0686	1.238E‐07	18.7	23.368	0.2215
rs79832570	SPATC1	8q24.3	145097720	C/T	0.086	0.1433	1.385E‐07	37.3	19.147	0.08504
rs13010870	RBM43	2q23.3	151765163	C/T	0.2162	−0.0732	1.649E‐07	0	18.774	0.5366
rs1354106	CD33	19q13.41	51737991	G/T	0.3441	−0.0614	1.673E‐07	6.4	21.373	0.3755
rs6014724	CASS4	20q13.2	54998544	G/A	0.0874	−0.1071	1.863E‐07	0	18.603	0.4825
rs897150	TRIB1	8q24.13	126576702	A/G	0.3016	−0.0634	2.33E‐07	4	20.842	0.4065
rs11168036	HBEGF	5q31.3	139707439	T/G	0.4933	0.0572	2.336E‐07	0	18.21	0.5735
rs17269688	NCK2	2q12.2	106469267	G/A	0.025	−0.1937	2.389E‐07	41.8	27.478	0.03647
rs677649	RNU6‐11P	7	123439244	T/G	0.1756	0.0851	2.505E‐07	9.9	19.987	0.3336
rs8081878	ZNF652	17q21.32	47436812	T/A	0.4634	0.057	2.609E‐07	9.9	22.19	0.3303
rs4654450	RP1‐37J18.2	1	4667378	G/A	0.3314	−0.0697	2.684E‐07	16.2	22.679	0.2518
rs11218343	SORL1	11q24.1	121435587	C/T	0.0364	−0.1658	2.909E‐07	20.7	21.432	0.2076
rs2297508	SREBF1	17p11.2	17715317	C/G	0.3659	−0.0585	4.604E‐07	31.9	29.367	0.08078
rs442495	ADAM10	15q21.3	59022615	C/T	0.3245	−0.0599	4.722E‐07	41	33.895	0.02684
rs13316744	AC091493.2	3	16742711	C/G	0.4544	−0.0549	7.609E‐07	0	15.72	0.7338
rs7068231	ANK3	10q21.2	61784928	T/G	0.4005	−0.0579	7.833E‐07	11.1	22.503	0.3139
rs834398	GABRB2	5q34	160528276	G/A	0.1971	0.0793	8.951E‐07	0	11.885	0.8905
rs62013908	RBFOX1	16p13.3	5991314	G/C	0.2547	0.0724	9.422E‐07	3.9	19.767	0.4087

Note: Genome‐wide significant variants are highlighted in orange.