TABLE 3.
Genome‐wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants associated with vascular dementia in European populations.
| rsID | Nearest gene | CHR | POS | EA/NEA | EAF |
BETA CHARGE |
p value CHARGE |
p value EADB |
p value COMBINED |
Direction |
|---|---|---|---|---|---|---|---|---|---|---|
| rs429358 | APOE | 19q13.32 | 45411941 | C/T | 0.1549 | 0.8794 | 2.67E‐86 | 5.66E‐113 | 2.9E‐196 | ++ |
| rs11911 | SPRY2 | 13q31.1 | 80910851 | C/A | 0.3756 | −0.1466 | 2.60E‐06 | 0.0653 | 0.0000335 | − |
| rs7101996 | GALNT18 | 11 | 11259298 | T/C | 0.4198 | −0.1362 | 3.06E‐06 | 0.48 | 0.00452 | −+ |
| rs2845990 | LINC02113 | 5 | 98907502 | C/T | 0.352 | −0.1383 | 3.24E‐06 | 0.872 | 0.00131 | −+ |
| rs117904289 | FOXA2 | 20p11.21 | 22782154 | G/A | 0.0858 | 0.2516 | 3.35E‐06 | 0.987 | 0.00112 | +− |
| rs838941 | SCARB1 | 12q24.31 | 125183316 | A/G | 0.4261 | 0.1344 | 3.56E‐06 | 0.33 | 0.0000654 | ++ |
| rs17418160 | ERBB4 | 2q34 | 213119022 | C/T | 0.0396 | 0.3341 | 3.58E‐06 | 0.882 | 0.00171 | +− |
| rs77542509 | TRPC6 | 11q22.1 | 101415824 | C/T | 0.058 | −0.3038 | 4.77E‐06 | 0.137 | 0.0000213 | − |
| rs6127311 | DOK5 | 20q13.2 | 53501017 | C/T | 0.0532 | −0.3141 | 4.83E‐06 | 0.294 | 0.0144 | +− |
| rs35945091 | LCN1P2 | 9 | 136185411 | C/T | 0.2227 | 0.164 | 5.15E‐06 | 0.855 | 0.00176 | +− |
| rs17059857 | ZNF236 | 18q23 | 74469493 | C/T | 0.0403 | 0.358 | 5.41E‐06 | 0.417 | 0.00934 | +− |
| rs143750890 | AJAP1 | 1p36.32 | 4602505 | C/T | 0.0273 | 0.4283 | 5.56E‐06 | 0.163 | 0.0000334 | ++ |
| rs9510987 | SPATA13 | 13 | 24575243 | G/T | 0.2525 | 0.1466 | 6.28E‐06 | 0.291 | 0.0000744 | − |
| rs55709546 | PHACTR3 | 20q13.32 | 58261107 | C/A | 0.0484 | 0.3044 | 6.53E‐06 | 0.645 | 0.000496 | ++ |
| rs12667855 | TMEM106B | 7p21.3 | 12124166 | T/G | 0.0981 | 0.225 | 6.59E‐06 | 0.542 | 0.000299 | ++ |
| rs281219 | SEMA6D | 15q21.1 | 47711652 | A/G | 0.1954 | 0.1641 | 6.65E‐06 | 0.316 | 0.0129 | +− |
| rs138352554 | GBP1 | 1p22.2 | 89517105 | G/A | 0.0359 | 0.3761 | 6.95E‐06 | 0.573 | 0.000406 | ++ |
| rs16967121 | RASGRP1 | 15q14 | 38923007 | G/A | 0.0658 | 0.2605 | 7.31E‐06 | 0.916 | 0.00126 | ++ |
| rs11007123 | WAC | 10p12.1 | 28763005 | C/T | 0.2804 | 0.1395 | 7.70E‐06 | 0.292 | 0.0139 | +− |
| rs4794009 | GIP | 17q21.32 | 47051955 | A/G | 0.4412 | 0.1274 | 8.17E‐06 | 0.797 | 0.000746 | ++ |
| rs35448830 | PRKCE | 2p21 | 46080762 | C/T | 0.0368 | 0.3346 | 8.48E‐06 | 0.631 | 0.000579 | ++ |
| rs2233754 | PSMA3 | 14q23.1 | 58755574 | C/A | 0.07 | 0.2575 | 9.39E‐06 | 0.601 | 0.00604 | +− |
Note: The meta‐analysis includes 11 cohorts from the CHARGE consortium and the UK Biobank (UKBB) GWAS. Direction denotes the direction of association in CHARGE and EADB. The genome‐wide significant variant is highlighted in orange.
Abbreviations: ADGC, Alzheimer's Disease Genetics Consortium; CHARGE, Cohorts for Heart and Aging Research in Genomic Epidemiology; EADB, European Alzheimer Disease Biobank; UKBB, UK Biobank.